2. Gene
  3. APOBEC3F - apolipoprotein B mRNA editing enzyme catalytic subunit 3F Gene

APOBEC3F - apolipoprotein B mRNA editing enzyme catalytic subunit 3F Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：载脂蛋白 B mRNA 编辑酶催化亚基 3F

种属: Homo sapiens

同用名: A3F; KA6; ARP8; BK150C2.4.MRNA

基因 ID: 200316 | 基因类型: protein coding

关于 APOBEC3F

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,040,864-39,055,972 (from NCBI)

This gene has 4 transcripts (splice variants), 52 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 2.8), ovary (RPKM 2.8) and 24 other tissues.

功能概要

该基因是胞苷脱氨酶基因家族的成员。它是在一个簇中发现的七个相关基因或假基因之一，被认为是由 22 号染色体上的基因复制引起的。该簇的成员编码的蛋白质在结构和功能上与 C 到 U RNA 编辑胞苷脱氨酶 APOBEC1 相关。人们认为这些蛋白质可能是 RNA 编辑酶，在生长或细胞周期控制中发挥作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing Enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

APOBEC3F 基因产物(2)

mRNA Protein Name
NM_001006666.2 NP_001006667.1 DNA dC->dU-editing enzyme APOBEC-3F isoform b
NM_145298.6 NP_660341.2 DNA dC->dU-editing enzyme APOBEC-3F isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
11863358 GOA
enables cytidine deaminase activity IDA
IDA: 通过直接分析推断
17121840 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23685212 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16699599 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
11863358 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA cytosine deamination IDA
IDA: 通过直接分析推断
21835787 GOA
involved in base conversion or substitution editing IDA
IDA: 通过直接分析推断
17121840 GOA
involved in clearance of foreign intracellular DNA IDA
IDA: 通过直接分析推断
20062055 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
21835787 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
17121840 GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: 通过直接分析推断
17121840 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
16378963 GOA
involved in negative regulation of viral process IDA
IDA: 通过直接分析推断
17121840 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
17121840 GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation IDA
IDA: 通过直接分析推断
21496894 GOA
involved in retrotransposon silencing IDA
IDA: 通过直接分析推断
16527742 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
16699599 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16527742 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
16699599 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APOBEC3F 蛋白结构

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (23 - 183)

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (200 - 371)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

DNA dC->dU-editing enzyme APOBEC-3F

apolipoprotein B editing enzyme catalytic polypeptide-like 3F

APOBEC3F 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
APOBEC3F Q8IUX4 APOBEC3F Homo sapiens Q8IUX4
X-Ray Diffraction
23685212
种属内
APOBEC3F Q8IUX4 APOBEC3F Homo sapiens Q8IUX4
DLS
23685212
种属内
APOBEC3F Q8IUX4 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
种属内
APOBEC3F Q8IUX4 APOBEC3G Homo sapiens Q9HC16
Anti Tag CoIP
15152192
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00839 APOBEC3F Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-120157 Vif-ElonginC interaction inhibitor 1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus APOBEC3F MGD MGI:1933111
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