1. Gene
  2. CTTN - cortactin Gene

CTTN - cortactin Gene

中文名称:皮质素

种属: Homo sapiens

同用名: EMS1

基因 ID: 2017 | 基因类型: protein coding

关于 CTTN

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:70,398,529-70,436,575 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 204 orthologues and 4 paralogues. Ubiquitous expression in gall bladder (RPKM 41.5), adrenal (RPKM 38.4) and 25 other tissues.

功能概要

该基因在乳腺癌和头颈部鳞状细胞癌中过度表达。编码的蛋白质位于细胞质和细胞-基质接触区域。该基因有两个作用: (1) 调节粘附型连接成分之间的相互作用和 (2) 组织上皮细胞和癌细胞的细胞骨架和细胞粘附结构。在细胞凋亡过程中,编码的蛋白质以半胱天冬酶依赖性方式降解。该基因的异常调节有助于肿瘤细胞的侵袭和转移。已经为该基因鉴定了编码不同亚型的三种剪接变体。[RefSeq 提供,2010 年 5 月]

This gene is overexpressed in breast Cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the Cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During Apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

CTTN 基因产物(3)

mRNA Protein Name
NM_001184740.2 NP_001171669.1 src substrate cortactin isoform c
NM_005231.4 NP_005222.2 src substrate cortactin isoform a
NM_138565.3 NP_612632.1 src substrate cortactin isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables profilin binding IPI
IPI: 通过物理相互作用推断
24700464 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15169891 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular protein transport IMP
IMP: 通过突变表型推断
17959782 GOA
involved in positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
24700464 GOA
involved in positive regulation of smooth muscle contraction IMP
IMP: 通过突变表型推断
24700464 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with actin filament IDA
IDA: 通过直接分析推断
12151401 GOA
located in cell cortex IDA
IDA: 通过直接分析推断
14742709 GOA
located in cortical cytoskeleton IDA
IDA: 通过直接分析推断
12151401 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10760273 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
10760273 GOA
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
12151401 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CTTN 蛋白结构

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (83 - 118)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (120 - 156)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (157 - 193)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (194 - 230)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (231 - 265)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (268 - 304)

HS1_rep

HS1_rep: Repeat in HS1/Cortactin (305 - 325)

SH3_9

SH3_9: Variant SH3 domain (499 - 547)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 550 a.a.
蛋白主名 其他名称

src substrate cortactin

1110020L01Rik

CTTN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CTTN Q14247 EGFR Homo sapiens P00533
Anti Tag CoIP
24658140
种属内
CTTN Q14247 HDAC6 Homo sapiens Q9UBN7
IF
21847094
种属内
CTTN Q14247 HDAC6 Homo sapiens Q9UBN7
Pull Down
21220424
种属内
CTTN Q14247 HDAC6 Homo sapiens Q9UBN7
Anti Bait CoIP
21847094
种属内
CTTN Q14247 HDAC6 Homo sapiens Q9UBN7
Anti Tag CoIP
33961781
种属内
CTTN Q14247 WAS Homo sapiens P42768
IF
15169891
种属内
CTTN Q14247 WAS Homo sapiens P42768
Anti Bait CoIP
15169891
种属内
CTTN Q14247 DNM2 Homo sapiens P50570
NMR
16636290
种属内
CTTN Q14247 DNM2 Homo sapiens P50570
GMS
16636290
种属内
CTTN Q14247 DNM2 Homo sapiens P50570
Pull Down
16636290
种属内
CTTN Q14247 ASAP1 Homo sapiens Q9ULH1
Pull Down
16636290
种属内
CTTN Q14247 ASAP1 Homo sapiens Q9ULH1
GMS
16636290
种属内
CTTN Q14247 ASAP1 Homo sapiens Q9ULH1
NMR
16636290
种属内
CTTN Q14247 ASAP1 Homo sapiens Q9ULH1
Competition Binding
16636290
种属内
CTTN Q14247 ASAP1 Homo sapiens Q9ULH1
DLS
16636290
种属间
CTTN Q14247 Srcin1 Mus musculus Q9QWI6-2
Anti Tag CoIP
19146815
种属间
CTTN Q14247 tir Escherichia coli O127:H6 B7UM99
Pull Down
19419567
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Ethmoid Sinus Adenocarcinoma

Adenocarcinoma Of Ethmoid Sinus

Adenocarcinoma Of The Ethmoid Sinus

Larynx Cancer

Laryngeal Carcinoma

Laryngeal Cancer

Laryngeal Neoplasm

Carcinoma Of Larynx

Malignant Neoplasm Of Larynx

Cancer Of Larynx

Laryngeal Neoplasms

Cancer, Laryngeal

Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Ethmoid Sinus Cancer

Malignant Neoplasm Of Ethmoidal Sinus

Malignant Tumor Of Ethmoid Sinus

Malignant Tumor Of Ethmoidal Sinus

Neoplasm Of Ethmoidal Sinus

Frank-Ter Haar Syndrome

Ter Haar Syndrome

Borrone Dermatocardioskeletal Syndrome

FTHS

Autosomal Recessive Melnick-Needles Syndrome

Borrone Di Rocco Crovato Syndrome

Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay

Melnick-Needles Syndrome, Autosomal Recessive, Formerly

Frank Ter Haar Syndrome

Bone Squamous Cell Carcinoma
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung

Squamous Cell Lung Carcinoma

Epidermoid Cell Carcinoma Of The Lung

Squamous Cell Lung Cancer

Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

Prolapse Of Urethra

Urethrocele

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CTTN VGNC VGNC:61274
Mus musculus CTTN MGD MGI:99695
Macaca mulatta CTTN VGNC VGNC:71611
Canis familiaris CTTN VGNC VGNC:39718
Bos taurus CTTN VGNC VGNC:27821
Rattus norvegicus CTTN RGD RGD:619839
Others CTTN NCBI