ENSA - endosulfine alpha Gene

中文名称：内硫素α

种属: Homo sapiens

同用名: ARPP-19e

关于 ENSA

功能概要

该基因编码的蛋白质属于高度保守的 cAMP 调节磷蛋白 (ARPP) 家族。该蛋白被鉴定为磺酰脲类受体 ABCC8/SUR1 的内源性配体。 ABCC8 是 ATP 敏感性钾 (KATP) 通道的调节亚基，位于胰腺 β 细胞的质膜上，在控制胰腺 β 细胞释放胰岛素方面起着关键作用。这种蛋白质被认为是 KATP 通道的内源性调节剂。体外研究表明，该蛋白通过与 KATP 通道相互作用调节胰岛素分泌，该基因已被提议作为 2 型糖尿病的候选基因。已观察到至少八种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of Insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates Insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]