2. Gene
  3. Sema4d - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Gene

Sema4d - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD100; Semaj; Semcl2; coll-4; Semacl2

基因 ID: 20354 | 基因类型: protein coding

关于 Sema4d

功能概要

Enables semaphorin receptor binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of inhibitory synapse assembly; and regulation of phosphate metabolic process. Acts upstream of or within positive regulation of axonogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human SEMA4D (semaphorin 4D). [provided by Alliance of Genome Resources, Apr 2022]

Sema4d 基因产物(15)

mRNA Protein Name
NM_001281880.2 NP_001268809.1 semaphorin-4D isoform 1 precursor
NM_001378313.1 NP_001365242.1 semaphorin-4D isoform 1 precursor
NM_001378314.1 NP_001365243.1 semaphorin-4D isoform 1 precursor
NM_001378315.1 NP_001365244.1 semaphorin-4D isoform 1 precursor
NM_001378316.1 NP_001365245.1 semaphorin-4D isoform 1 precursor
NM_001378317.1 NP_001365246.1 semaphorin-4D isoform 2 precursor
NM_001378318.1 NP_001365247.1 semaphorin-4D isoform 2 precursor
NM_001378319.1 NP_001365248.1 semaphorin-4D isoform 2 precursor
NM_001378320.1 NP_001365249.1 semaphorin-4D isoform 3 precursor
NM_001378321.1 NP_001365250.1 semaphorin-4D isoform 3 precursor
NM_001378322.1 NP_001365251.1 semaphorin-4D isoform 3 precursor
NM_001378323.1 NP_001365252.1 semaphorin-4D isoform 3 precursor
NM_001378324.1 NP_001365253.1 semaphorin-4D isoform 4 precursor
NM_001378325.1 NP_001365254.1 semaphorin-4D isoform 5
NM_013660.5 NP_038688.2 semaphorin-4D isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
2917992 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
22019888 MGI
enables semaphorin receptor binding IPI
IPI: 通过物理相互作用推断
22019888 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
15330859 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of axonogenesis IDA
IDA: 通过直接分析推断
15330859 MGI
acts upstream of axonogenesis IGI
IGI: 通过遗传相互作用推断
15330859 MGI
involved in bone trabecula morphogenesis IMP
IMP: 通过突变表型推断
22019888 MGI
involved in negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
22019888 MGI
involved in negative regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
22019888 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22019888 MGI
involved in ossification involved in bone maturation IMP
IMP: 通过突变表型推断
22019888 MGI
involved in positive regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
22019888 MGI
acts upstream of or within positive regulation of axonogenesis IDA
IDA: 通过直接分析推断
15330859 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: 通过遗传相互作用推断
15330859 MGI
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
22019888 MGI
involved in positive regulation of inhibitory synapse assembly IDA
IDA: 通过直接分析推断
23699507 MGI
involved in positive regulation of inhibitory synapse assembly IMP
IMP: 通过突变表型推断
29981480 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
22019888 MGI
involved in regulation of synapse assembly IDA
IDA: 通过直接分析推断
24036351 MGI
involved in regulation of synapse assembly IMP
IMP: 通过突变表型推断
24036351 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: 通过突变表型推断
22019888 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
24036351 MGI
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
24036351 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
22019888 MGI
part of semaphorin receptor complex IMP
IMP: 通过突变表型推断
22019888 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

semaphorin-4D

M-sema G

sema J

semaphorin H

semaphorin-C-like 2

semaphorin-J

重组 Sema4d 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72478 Semaphorin-4D/SEMA4D Protein, Mouse (HEK293, Fc) O09126 (F24-M711) ≥95%
HY-P74563 Semaphorin-4D/SEMA4D Protein, Mouse (HEK293, His) O09126 (M1-R733) ≥95%
HY-P700429 Semaphorin-4D/SEMA4D Protein, Mouse (HEK293, mFc) O09126 (F24-R733) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12660 SEMA4D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sema4d NCBI NCBI:10507
Macaca fascicularis Sema4d NCBI NCBI:102132571
Rattus norvegicus Sema4d NCBI NCBI:306790
Macaca mulatta Sema4d NCBI NCBI:697697
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