2. Gene
  3. SEMA4D - semaphorin 4D Gene

SEMA4D - semaphorin 4D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号素 4D

种属: Homo sapiens

同用名: A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G

基因 ID: 10507 | 基因类型: protein coding

关于 SEMA4D

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,360,787-89,498,113 (from NCBI)

This gene has 24 transcripts (splice variants), 192 orthologues, 19 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues.

功能概要

实现相同的蛋白质结合活性；信号素受体结合活性；和跨膜信号受体活性。参与多个过程，包括磷脂酰肌醇 3-激酶信号的正调节；调节神经元投射发育；磷酸盐代谢过程的调节。是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase signaling; regulation of neuron projection development; and regulation of phosphate metabolic process. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4D 基因产物(11)

mRNA Protein Name
NM_001142287.2 NP_001135759.1 semaphorin-4D isoform 2 precursor
NM_001371194.2 NP_001358123.1 semaphorin-4D isoform 1 precursor
NM_001371195.1 NP_001358124.1 semaphorin-4D isoform 1 precursor
NM_001371196.1 NP_001358125.1 semaphorin-4D isoform 1 precursor
NM_001371197.1 NP_001358126.1 semaphorin-4D isoform 1 precursor
NM_001371198.1 NP_001358127.1 semaphorin-4D isoform 2 precursor
NM_001371199.1 NP_001358128.1 semaphorin-4D isoform 2 precursor
NM_001371200.1 NP_001358129.1 semaphorin-4D isoform 2 precursor
NM_001371201.1 NP_001358130.1 semaphorin-4D isoform 2 precursor
NM_001371202.1 NP_001358131.1 semaphorin-4D isoform 3 precursor
NM_006378.4 NP_006369.3 semaphorin-4D isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20877282 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20877282 GOA
enables semaphorin receptor binding IPI
IPI: 通过物理相互作用推断
15218527 GOA
enables signaling receptor activity IDA
IDA: 通过直接分析推断
15613544 GOA
enables signaling receptor binding IDA
IDA: 通过直接分析推断
11254688 GOA
enables transmembrane signaling receptor activity IMP
IMP: 通过突变表型推断
20877282 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in leukocyte aggregation IMP
IMP: 通过突变表型推断
8876214 GOA
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
15218527 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22019888 GOA
involved in ossification involved in bone maturation IMP
IMP: 通过突变表型推断
22019888 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
19788569 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
16055703 GOA
involved in positive regulation of collateral sprouting IMP
IMP: 通过突变表型推断
19788569 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
16055703 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
16055703 GOA
involved in regulation of cell projection organization IMP
IMP: 通过突变表型推断
20877282 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
20877282 GOA
involved in regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
19788569 GOA
involved in semaphorin-plexin signaling pathway IDA
IDA: 通过直接分析推断
15218527 GOA
involved in semaphorin-plexin signaling pathway IMP
IMP: 通过突变表型推断
19788569 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
8876214 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEMA4D 蛋白结构

Sema

Sema: Sema domain (50 - 481)

PSI

PSI: Plexin repeat (503 - 554)

ig

ig: Immunoglobulin domain (569 - 624)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 862 a.a.
蛋白主名 其他名称

semaphorin-4D

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

重组 SEMA4D 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7774 Semaphorin-4D/SEMA4D Protein, Human (HEK293, His) Q92854-1 (M22-R734) ≥95%
HY-P74565 Semaphorin-4D/SEMA4D Protein, Human (HEK293, hFc) AAH54500.1 (M22-R734) ≥95%
HY-P77194 Semaphorin-4D/SEMA4D Protein, Rhesus Macaque (HEK293, His) EHH24221.1 (M22-R734) ≥95%
HY-P78202 Semaphorin-4D/SEMA4D Protein, Human (Biotinylated, HEK293, His-Avi) Q92854-1 (M22-R734) ≥95%
HY-P78512 Semaphorin-4D/SEMA4D Protein, Human (HEK293, His-Avi) Q92854-1 (M22-R734) ≥95%

关联疾病

疾病名称 别名
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Osteonecrosis Of The Jaw
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12660 SEMA4D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SEMA4D VGNC VGNC:34436
Canis familiaris SEMA4D VGNC VGNC:53974
Mus musculus SEMA4D MGD MGI:109244
Macaca mulatta SEMA4D VGNC VGNC:77166
Felis catus SEMA4D VGNC VGNC:64995
Rattus norvegicus SEMA4D RGD RGD:1310554
Macaca fascicularis SEMA4D NCBI NCBI:102132571
Others SEMA4D NCBI
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