Sgk1 - serum/glucocorticoid regulated kinase 1 Gene

中文名称：血清/糖皮质激素调节激酶 1

种属: Mus musculus

同用名: Sgk

关于 Sgk1

功能概要

该基因编码在细胞应激反应中起重要作用的丝氨酸/苏氨酸蛋白激酶。这种激酶激活某些钾、钠和氯通道，表明参与细胞存活、神经元兴奋性和肾钠排泄等过程的调节。这种酶被蛋白质磷酸化激活，并通过泛素化和蛋白酶体途径降解。已发现该基因编码不同异构体的多个转录变体。该基因的假基因在 12 号染色体上被鉴定出来。[RefSeq 提供，2009 年 9 月]

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This Enzyme is activated by protein phosphorylation and degraded via the ubiquitination and Proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]