EPHB3 - EPH receptor B3 Gene

中文名称：EPH 受体 B3

种属: Homo sapiens

同用名: EK2; ETK2; HEK2; TYRO6

关于 EPHB3

功能概要

肝配蛋白受体及其配体肝配蛋白介导许多发育过程，尤其是在神经系统中。基于它们的结构和序列关系，肝配蛋白分为肝配蛋白-A (EFNA) 类和肝配蛋白 B (EFNB) 类，前者通过糖基磷脂酰肌醇键固定在膜上，后者是跨膜蛋白。 Eph 受体家族根据其细胞外结构域序列的相似性及其对结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力分为两组。 Ephrin 受体构成受体酪氨酸激酶 (RTK) 家族的最大亚群。该基因编码 ephrin-B 家族成员的受体。[RefSeq 提供，2010 年 3 月]

Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]