2. Gene
  3. Spp1 - secreted phosphoprotein 1 Gene

Spp1 - secreted phosphoprotein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: OP; 2AR; Bsp; Eta; Opn; Ric; BNSP; BSPI; Opnl; Apl-1; ETA-1; Spp-1

基因 ID: 20750 | 基因类型: protein coding

关于 Spp1

功能概要

Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Spp1 基因产物(5)

mRNA Protein Name
NM_001204201.1 NP_001191130.1 osteopontin isoform 1
NM_001204202.1 NP_001191131.1 osteopontin isoform 2
NM_001204203.1 NP_001191132.1 osteopontin isoform 3 precursor
NM_001204233.1 NP_001191162.1 osteopontin isoform 4 precursor
NM_009263.3 NP_033289.2 osteopontin isoform 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellular matrix binding IDA
IDA: 通过直接分析推断
18757743 MGI
enables integrin binding IDA
IDA: 通过直接分析推断
22654117 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone mineralization IDA
IDA: 通过直接分析推断
12817751 MGI
involved in bone mineralization IMP
IMP: 通过突变表型推断
12817751 MGI
involved in calcium ion homeostasis IDA
IDA: 通过直接分析推断
12817751 MGI
acts upstream of or within cellular response to fluid shear stress IDA
IDA: 通过直接分析推断
24841674 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within collecting duct development IMP
IMP: 通过突变表型推断
17898038 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
17898038 MGI
acts upstream of or within intracellular chloride ion homeostasis IMP
IMP: 通过突变表型推断
17898038 MGI
acts upstream of or within intracellular phosphate ion homeostasis IMP
IMP: 通过突变表型推断
17898038 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: 通过突变表型推断
17898038 MGI
acts upstream of or within neutrophil chemotaxis IDA
IDA: 通过直接分析推断
21321126 MGI
acts upstream of or within neutrophil chemotaxis IGI
IGI: 通过遗传相互作用推断
21321126 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
18757743 MGI
acts upstream of or within urate biosynthetic process IMP
IMP: 通过突变表型推断
17898038 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
16518820 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
16518820 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

osteopontin

44 kDa bone phosphoprotein

bone sialoprotein 1

calcium oxalate crystal growth inhibitor protein

early T-lymphocyte activation 1 protein

minopontin

osteopontin-like protein

重组 Spp1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71786 Osteopontin/OPN Protein, Mouse (P.pastoris, His) P10923 (L17-S290) ≥95%
HY-P78358 Osteopontin/OPN Protein, Mouse (HEK293, His) P10923 (L17-N294) ≥95%

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-108009A Rezafungin acetate Inhibitor 98.15% 是
HY-108009 Rezafungin Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-104029 Olorofim Inhibitor 99.57% Phase 2
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-B2060A Tiamulin fumarate Inhibitor ≥98.0% 否
HY-113491 3-Phosphoglyceric acid 99.78% 否
HY-B2060 Tiamulin Inhibitor 98.07% 否
HY-RS13702 SPP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16219 SPP1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-126491 SPP-DM1 ≥95.0% 否
HY-N6695 Aflatoxicol ≥99.0% 否
HY-W020785 Fosthiazate Inhibitor 95.27% 否
HY-116479 Citromycetin / 否
HY-12613 2-C-methylene-myo-inositol oxide / 否
HY-136380S Clodinafop-propargyl-13C6 / 否
HY-139746 FPI-1602 Inhibitor / 否
HY-164207 VLPA-GlcNAc / 否
HY-N2340A D-(+)-Melezitose hydrate ≥98.0% 否
HY-N2728 6-O-Syringoylajugol / 否
HY-P0068 Aminocandin Inhibitor / 否
HY-120729 Pyrazophos Inhibitor / 否
HY-N11995 allo-Aloeresin D / 否
HY-N12882 (Z)-10-Hexadecen-1-ol / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spp1 NCBI NCBI:6696
Macaca fascicularis Spp1 NCBI NCBI:102137879
Rattus norvegicus Spp1 NCBI NCBI:25353
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