Stat6 - signal transducer and activator of transcription 6 Gene

中文名称：信号转导和转录激活因子 6

种属: Mus musculus

关于 Stat6

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与白细胞介素 4 介导的信号通路和冷诱导产热的正向调节。作用于多个过程的上游或内部，包括 T-helper 1 细胞谱系承诺；乳腺发育；和调节含核碱基的化合物代谢过程。位于染色质；细胞质；和核。以多种结构表达，包括 2 细胞期胚胎；消化系统；下泌尿道;男性生殖系统；和嗅觉上皮。该基因的人类直系同源物与类脂肾病有关；前列腺癌；和尿血吸虫病。与人类 STAT6（信号转导和转录激活因子 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interleukin-4-mediated signaling pathway and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]