Hdac4 - histone deacetylase 4 Gene

中文名称：组蛋白脱乙酰酶 4

种属: Mus musculus

同用名: HD4; 4932408F19Rik

关于 Hdac4

功能概要

该基因编码的蛋白可启动多种功能，包括染色质结合活性；蛋白质脱乙酰酶活性；和转录辅阻遏物活性。参与调节含核碱基的复合代谢过程和对参与肌肉适应调节的去神经支配的反应。在几个过程的上游或内部起作用，包括成骨细胞分化的负调节；成骨细胞发育；以及通过钙离子信号调节心肌收缩。位于几种细胞成分中，包括肌动球蛋白；胞质溶胶；和神经肌肉接头。以多种结构表达，包括消化系统；早期胚胎；神经节;手;和端脑。用于研究饮食失调。该基因的人类直系同源物与共济失调毛细血管扩张有关；染色体 2q37 缺失综合征；饮食失调；和视网膜变性。与人类 HDAC4（组蛋白脱乙酰酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including chromatin binding activity; protein deacetylase activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of cardiac muscle contraction by calcium ion signaling. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; ganglia; hand; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]