Skp1 - S-phase kinase-associated protein 1 Gene

种属: Mus musculus

同用名: OCP2; p19A; 15kDa; EMC19; Skp1a; OCP-II; Tceb1l; p19Skp1; 2610043E24Rik; 2610206H23Rik

关于 Skp1

功能概要

Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in centrosome and cytosol. Part of Cul7-RING ubiquitin Ligase complex and SCF ubiquitin Ligase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; notochord; and sensory organ. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]