1. Gene
  2. Astl - astacin-like metalloendopeptidase (M12 family) Gene

Astl - astacin-like metalloendopeptidase (M12 family) Gene

种属: Mus musculus

同用名: Sas1b; 7420700F21

基因 ID: 215095 | 基因类型: protein coding

关于 Astl

功能概要

Enables aspartic-type peptidase activity and glutamic-type peptidase activity. Involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Located in cortical granule and plasma membrane. Is expressed in early conceptus and oocyte. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Astl 基因产物(2)

mRNA Protein Name
NM_001291003.1 NP_001277932.1 astacin-like metalloendopeptidase isoform a precursor
NM_172539.3 NP_766127.1 astacin-like metalloendopeptidase isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic-type peptidase activity IDA
IDA: 通过直接分析推断
22472438 MGI
enables glutamic-type peptidase activity IDA
IDA: 通过直接分析推断
22472438 MGI
enables peptidase activity IDA
IDA: 通过直接分析推断
22206759 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22206759 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell adhesion IMP
IMP: 通过突变表型推断
22206759 MGI
involved in fertilization IMP
IMP: 通过突变表型推断
22206759 MGI
involved in negative regulation of binding of sperm to zona pellucida IDA
IDA: 通过直接分析推断
22472438 MGI
involved in positive regulation of protein processing IDA
IDA: 通过直接分析推断
22472438 MGI
involved in prevention of polyspermy IDA
IDA: 通过直接分析推断
22472438 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cortical granule IDA
IDA: 通过直接分析推断
22472438 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
22206759 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
22206759 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

astacin-like metalloendopeptidase

oocyte astacin

ovastacin

sperm acrosomal SLLP1

sperm acrosomal SLLP1-binding protein

重组 Astl 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77566 ASTL/SAS1B Protein, Mouse (His) Q6HA09-1 (A24-D435) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Astl NCBI NCBI:431705