2. Gene
  3. Plk5 - polo like kinase 5 Gene

Plk5 - polo like kinase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：马球样激酶 5

种属: Mus musculus

同用名: 6330514A18Rik

基因 ID: 216166 | 基因类型: protein coding

关于 Plk5

Chromosome 10: 80,192,293-80,201,323 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 98 orthologues and 4 paralogues. Biased expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 4.7) and 6 other tissues.

功能概要

预测该基因编码的蛋白可启动 ATP 绑定活动；金属离子结合活性；和蛋白激酶活性。参与多个过程，包括对肿瘤细胞的防御反应；神经元投射发育的正向调节；和调节有丝分裂细胞周期的 G1/S 转换。位于核仁。以多种结构表达，包括中枢神经系统；眼睛;和卵巢。与人类 PLK5（马球样激酶 5（无活性））同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in nucleolus. Is expressed in several structures, including central nervous system; eye; and ovary. Orthologous to human PLK5 (polo like kinase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]

Plk5 基因产物(2)

mRNA Protein Name
NM_183152.4 NP_898975.2 inactive serine/threonine-protein kinase PLK5 isoform 1
NM_001347124.1 NP_001334053.1 inactive serine/threonine-protein kinase PLK5 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables kinase activity IDA
IDA: 通过直接分析推断
21245385 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
20100802 MGI
involved in defense response to tumor cell IDA
IDA: 通过直接分析推断
21245385 MGI
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
21245385 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
20100802 MGI
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
21245385 MGI
involved in regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
20100802 MGI
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
21245385 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
20100802 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Plk5 蛋白结构

STKc_PLK

STKc_PLK: cd14099 (24 - 278)

POLO_box_1

POLO_box_1: cd13118 (409 - 496)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
蛋白主名 其他名称

inactive serine/threonine-protein kinase PLK5

PLK-5

serine/threonine-protein kinase PLK5

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10723 PLK5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10724 Plk5 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10725 Plk5 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plk5 NCBI NCBI:126520
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