Tlr1 - toll-like receptor 1 Gene

中文名称：Toll样受体 1

种属: Mus musculus

关于 Tlr1

功能概要

预计该基因编码的蛋白具有多种功能，包括 Toll 样受体 2 结合活性；相同的蛋白质结合活性；和脂肽结合活性。参与白介素 6 生成的正调节和肿瘤坏死因子生成的正调节。在防御反应的上游或内部行动。预测位于高尔基体和膜筏。预计是 Toll 样受体 1-Toll 样受体 2 蛋白复合物的一部分。预计是质膜的组成部分。在大脑皮层和端脑中表达。该基因的人类直系同源基因与多种疾病有关，包括 IgA 肾小球肾炎；曲霉病;麻风;肾盂肾炎;和肺结核。与人类 TLR1（toll 样受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including Toll-like Receptor 2 binding activity; identical protein binding activity; and Lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 1-Toll-like receptor 2 protein complex. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]