STOX1 - storkhead box 1 Gene

中文名称：鹳头盒 1

种属: Homo sapiens

同用名: C10orf24

基因 ID: 219736 | 基因类型: protein coding

关于 STOX1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:68,827,531-68,895,432 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in brain (RPKM 2.8), fat (RPKM 2.4) and 21 other tissues.

功能概要

由该基因编码的蛋白质可作为 DNA 结合蛋白发挥作用。该基因的突变与先兆子痫/子痫 4 (PEE4) 有关。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2009 年 9 月]

The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

STOX1 基因产物(4)

mRNA	Protein	Name
NM_001130159.3	NP_001123631.1	storkhead-box protein 1 isoform b
NM_001130160.3	NP_001123632.1	storkhead-box protein 1 isoform c
NM_001130161.4	NP_001123633.1	storkhead-box protein 1 isoform a
NM_152709.5	NP_689922.3	storkhead-box protein 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	22253775	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to nitrosative stress	IMP IMP: 通过突变表型推断	24738702	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	22253775	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	22253775	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	22253775	GOA
involved in positive regulation of cyclin-dependent protein kinase activity	IMP IMP: 通过突变表型推断	22253775	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	22253775	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	22995177	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: 通过突变表型推断	22995177	GOA
involved in regulation of gene expression	IMP IMP: 通过突变表型推断	24738702	GOA
involved in regulation of mitochondrial DNA metabolic process	IMP IMP: 通过突变表型推断	24738702	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: 通过突变表型推断	24738702	GOA
involved in regulation of mitochondrion organization	IMP IMP: 通过突变表型推断	24738702	GOA
involved in regulation of response to oxidative stress	IMP IMP: 通过突变表型推断	24738702	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	24738702	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	22253775	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	22253775	GOA
located in nucleus	IDA IDA: 通过直接分析推断	22253775	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STOX1 蛋白结构

Stork_head

0
200
400
600
800
989 a.a.

蛋白主名

其他名称

storkhead-box protein 1

winged-helix domain-containing protein

STOX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STOX1	Q6ZVD7	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
种属内	STOX1	Q6ZVD7	ADARB1	Homo sapiens	P78563-4	Y2H Array	32296183
种属内	STOX1	Q6ZVD7	ADARB1	Homo sapiens	P78563-4	Y2H Prey Pooling	32296183
种属内	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
种属内	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
种属内	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Preeclampsia/Eclampsia 4

PEE4	Pre-Eclampsia/Eclampsia 4
Gestational Proteinuric Hypertension	Preeclampsia/Eclampsia, Type 4
Preeclampsia Eclampsia 4

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Severe Pre-Eclampsia

Severe Preeclampsia	Antepartum Severe Pre-Eclampsia
Postpartum Severe Pre-Eclampsia	Severe Pre-Eclampsia, With Delivery
Severe Toxemia	Severe Pre-Eclampsia, Antepartum Condition Or Complication
Severe Pre-Eclampsia, Postpartum Condition Or Complication	Severe Puerperal Pre-Eclampsia
Severe Pre-Eclamptic Toxaemia	Severe Pet - [Pre-Eclamptic Toxaemia]

Patau Syndrome

Trisomy 13	Complete Trisomy 13 Syndrome
Trisomy 13 Syndrome	D1 Trisomy
Patau'S Syndrome	Complete Trisomy 13
Chromosome 13, Trisomy 13 Complete	D Trisomy Syndrome
Bartholin-Patau Syndrome	Chromosome 13 Duplication
D1 Trisomy Syndrome	D>1< Trisomy Syndrome
Patau	Chromosome 13 Trisomy
Abnormal Autosomes 13

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13954	STOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	STOX1	VGNC	VGNC:35414
Canis familiaris	STOX1	VGNC	VGNC:49791
Macaca mulatta	STOX1	VGNC	VGNC:78197
Mus musculus	STOX1	MGD	MGI:2684909
Rattus norvegicus	STOX1	RGD	RGD:1310622

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STOX1 - storkhead box 1 Gene

关于 STOX1

功能概要

STOX1 基因产物(4)

STOX1 蛋白结构

STOX1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

STOX1 - storkhead box 1 Gene

关于 STOX1

功能概要

STOX1 基因产物(4)

STOX1 蛋白结构

STOX1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z