2. Gene
  3. FCER1A - Fc epsilon receptor Ia Gene

FCER1A - Fc epsilon receptor Ia Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Fc ε 受体 Ia

种属: Homo sapiens

同用名: FCE1A; FcERI; FCERIA

基因 ID: 2205 | 基因类型: protein coding

关于 FCER1A

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,283,575-159,308,202 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 17 paralogues. Broad expression in skin (RPKM 12.7), esophagus (RPKM 10.4) and 20 other tissues.

功能概要

免疫球蛋白ε受体 (IgE 受体) 是过敏反应的引发剂。当两个或多个高亲和力 IgE 受体被过敏原结合的 IgE 分子聚集在一起时，会释放引起过敏症状的介质，例如组胺。该受体由一个α亚基、一个β亚基和两个γ亚基组成。该基因编码的蛋白质代表α亚基。[RefSeq 提供，2011 年 8 月]

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

FCER1A 基因产物(4)

mRNA Protein Name
NM_001387280.1 NP_001374209.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor
NM_001387281.1 NP_001374210.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 3 precursor
NM_001387282.1 NP_001374211.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 2 precursor
NM_002001.4 NP_001992.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables IgE binding IDA
IDA: 通过直接分析推断
10917520 GOA
enables high-affinity IgE receptor activity IDA
IDA: 通过直接分析推断
8114916 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10917520 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in eosinophil degranulation IDA
IDA: 通过直接分析推断
8114916 GOA
involved in mast cell degranulation IMP
IMP: 通过突变表型推断
8551243 GOA
involved in type 2 immune response IDA
IDA: 通过直接分析推断
8114916 GOA
involved in type I hypersensitivity IMP
IMP: 通过突变表型推断
8551243 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
1535625 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
8114916 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FCER1A 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (30 - 104)

Ig_2

Ig_2: Immunoglobulin domain (114 - 194)

  • 0
  • 100
  • 200
  • 257 a.a.
蛋白主名 其他名称

high affinity immunoglobulin epsilon receptor subunit alpha

Fc IgE receptor, alpha polypeptide

FCER1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FCER1A P12319 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
种属内
FCER1A P12319 MESD Homo sapiens Q14696
Validated Y2H
32296183
种属内
FCER1A P12319 MESD Homo sapiens Q14696
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FCER1A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72191 Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) P12319 (V26-Q205) ≥95%

关联疾病

疾病名称 别名
Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Physical Urticaria

Symptomatic Dermographism
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism
Allergic Rhinitis

Hay Fever

Allergic Rhinitis, Susceptibility To

ALRH

Atopic Rhinitis

Seasonal Allergic Rhinitis

Non-Seasonal Allergic Rhinitis

Perenial Allergic Rhinitis

Pollenosis

Rhinitis Allergic Seasonal

Rhinitis, Allergic, Perennial

Allergic Rhinitis, Cause Unspecified

Pollinosis

Pollen Allergy

Allergy Nos Due To Pollen

Summer Catarrh

Other Seasonal Allergic Rhinitis
Amoxicillin Allergy
Chronic Inducible Urticaria
Cholinergic Urticaria
Allergic Urticaria
Trombiculiasis
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04822 FCER1A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FCER1A VGNC VGNC:28930
Felis catus FCER1A VGNC VGNC:62208
Canis familiaris FCER1A VGNC VGNC:40801
Macaca mulatta FCER1A VGNC VGNC:72628
Mus musculus FCER1A MGD MGI:95494
Rattus norvegicus FCER1A RGD RGD:2597
Others FCER1A NCBI
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