Fc epsilon RIA/FCER1A 蛋白, Human (His-SUMO)

The Fc epsilon RIA/FCER1A protein is a high-affinity receptor for IgE and critically mediates IgE effector function in myeloid cells. After binding to IgE and cross-linking with antigen, it activates signaling pathways that induce myeloid cell activation and differentiation. Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) is the recombinant human-derived Fc epsilon RIA/FCER1A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) is 180 a.a., with molecular weight of ~37 kDa.

Fc epsilon RIA/FCER1A 蛋白作为专为免疫球蛋白 epsilon/IgE 设计的高亲和力受体占据中心地位，充当骨髓细胞中 IgE 效应器功能的关键介质。与 IgE 结合并随后与抗原/过敏原交联后，它会激活诱导骨髓细胞活化和分化的信号传导途径。特别是在肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞上，Fc epsilon RIA 会触发血管活性胺、脂质介质和细胞因子的分泌，从而促进炎症反应、组织重塑和针对微生物的细胞毒性。这种精心策划的反应构成了对过敏原的立即超敏反应的一部分，充当针对蠕虫寄生虫、病原菌和毒液毒性的宿主防御机制。然而，当失调时，这种受体可能会导致有害且危及生命的过敏和过敏反应。在结构上，它以四聚体形式存在，包含一条 α 链、一条 β 链和两条二硫键连接的 γ 链，并通过 CH3 区域与 IGHE 相互作用。

Human

E. coli

N-6*His;N-SUMO

P12319 (V26-Q205)

2205  [NCBI]

VPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQ

Approximately 37 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.