UCMA - upper zone of growth plate and cartilage matrix associated Gene

中文名称：生长板的上部区域和相关的软骨基质

种属: Homo sapiens

同用名: GRP; C10orf49; GRP/UCMA

关于 UCMA

功能概要

该基因编码一种软骨细胞特异性、高电荷的蛋白质，该蛋白质在胎儿和幼年骨骺软骨的上层未成熟区大量表达。编码的蛋白质经过蛋白水解加工，生成分泌到细胞外基质中的成熟蛋白质。编码蛋白质中的谷氨酸残基以维生素 K 依赖性方式进行 γ 羧化。编码蛋白的羧基化不足与人类的骨关节炎有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 7 月]

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]