ZUP1 - zinc finger containing ubiquitin peptidase 1 Gene

中文名称：含锌指的泛素肽酶 1

种属: Homo sapiens

同用名: DUB; ZUFSP; C6orf113

关于 ZUP1

功能概要

该基因编码含有锌指基序和半胱氨酸肽酶结构域的蛋白质。编码的蛋白质起着一种 K63 特异性去泛素化酶的作用，它特异性地切割链中间的 K63 连接的多聚泛素长链 (即“内切裂解”) ，而不是通过从链中去除末端泛素。这种酶被认为通过在修复灶处切割 K63 连接的泛素链参与 DNA 修复的调节。该蛋白质与泛素样修饰剂 Ufm1 (泛素折叠修饰剂 1) 和 Atg8/Gabarapl2 的蛋白酶相关，但对这些修饰符。[RefSeq 提供，2018 年 3 月]

This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating Enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This Enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]