Ttr - transthyretin Gene

中文名称：转甲状腺素蛋白

种属: Mus musculus

同用名: prealbumin

关于 Ttr

功能概要

该基因编码负责运输甲状腺激素和视黄醇的载体蛋白。该蛋白质由相同亚基的四聚体组成。由于该编码蛋白的四聚体形式在小鼠中的稳定性增加，与人类蛋白相比，该基因产物形成淀粉样原纤维的趋势降低。在人类中，这种蛋白质结合 β-淀粉样蛋白，防止其聚集并在阿尔茨海默病中发挥神经保护作用。 [RefSeq 提供，2010 年 3 月]

This gene encodes a carrier protein responsible for the transport of thyroid Hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]