2. Gene
  3. OARD1 - O-acyl-ADP-ribose deacylase 1 Gene

OARD1 - O-acyl-ADP-ribose deacylase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：O-酰基-ADP-核糖脱酰酶 1

种属: Homo sapiens

同用名: TARG1; C6orf130; dJ34B21.3

基因 ID: 221443 | 基因类型: protein coding

关于 OARD1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,064,772-41,097,787 (from NCBI)

This gene has 16 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in testis (RPKM 36.5), thyroid (RPKM 20.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种脱酰酶，可将 O-乙酰基-ADP-核糖转化为 ADP-核糖和乙酸，将 O-丙酰基-ADP-核糖转化为 ADP-核糖和丙酸，将 O-丁酰基-ADP-核糖转化为 ADP -核糖和丁酸盐。 ADP-核糖产物能够通过竞争性反馈回路抑制这些反应。[RefSeq 提供，2016 年 7 月]

The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]

OARD1 基因产物(13)

mRNA Protein Name
NM_001329684.2 NP_001316613.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329685.1 NP_001316614.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329686.2 NP_001316615.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329688.2 NP_001316617.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329689.2 NP_001316618.1 ADP-ribose glycohydrolase OARD1 isoform b
NM_001329690.2 NP_001316619.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329691.2 NP_001316620.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329692.1 NP_001316621.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329693.2 NP_001316622.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329694.2 NP_001316623.1 ADP-ribose glycohydrolase OARD1 isoform d
NM_001329695.1 NP_001316624.1 ADP-ribose glycohydrolase OARD1 isoform d
NM_001329696.2 NP_001316625.1 ADP-ribose glycohydrolase OARD1 isoform d
NM_145063.4 NP_659500.1 ADP-ribose glycohydrolase OARD1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP-ribosylglutamate hydrolase activity IDA
IDA: 通过直接分析推断
23474714 GOA
enables O-acetyl-ADP-ribose deacetylase activity IDA
IDA: 通过直接分析推断
21849506 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23481255 GOA
enables purine nucleoside binding IDA
IDA: 通过直接分析推断
21849506 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
23481255 GOA
involved in peptidyl-glutamate ADP-deribosylation IDA
IDA: 通过直接分析推断
23474714 GOA
involved in protein de-ADP-ribosylation IDA
IDA: 通过直接分析推断
23474714 GOA
involved in purine nucleoside metabolic process IDA
IDA: 通过直接分析推断
21849506 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
29712969 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
29712969 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
23481255 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OARD1 蛋白结构

Macro

Macro: Macro domain (35 - 134)

  • 0
  • 100
  • 152 a.a.
蛋白主名 其他名称

ADP-ribose glycohydrolase OARD1

O-acetyl-ADP-ribose deacetylase 1

OARD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OARD1 Q9Y530 TNKS Homo sapiens O95271
Y2H Prey Pooling
32296183
种属内
OARD1 Q9Y530 TNKS Homo sapiens O95271
Y2H Array
32296183
种属内
OARD1 Q9Y530 PARP10 Homo sapiens Q53GL7
Enzymatic Study
23481255
种属内
OARD1 Q9Y530 PARP1 Homo sapiens P09874
Enzymatic Study
23481255
种属内
OARD1 Q9Y530 PARP1 Homo sapiens P09874
Anti Tag CoIP
23481255
种属内
OARD1 Q9Y530 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属内
OARD1 Q9Y530 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 OARD1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71658 OARD1 Protein, Human (Myc, His) Q9Y530 (A2-L152) ≥95%

关联疾病

疾病名称 别名
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Brachydactyly, Type A4

Brachymesophalangy Ii And V

Temtamy Type Brachydactyly

Brachydactyly Type A4

BDA4

Brachymesophalangy 2 And 5

Brachydactyly Temtamy Type

Brachydactyly, Temtamy Type
Eastern Equine Encephalitis

Eee

Neuroinvasive Eastern Equine Encephalitis Virus Infection

Eastern Equine Encephalomyelitis

Encephalomyelitis, Eastern Equine

Triple E

Eastern Equine Encephalitis Virus Infection

Neuroinvasive Eastern Equine Encephalitis Virus Disease

Eee - [Eastern Equine Encephalitis]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09726 OARD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus OARD1 VGNC VGNC:32390
Felis catus OARD1 VGNC VGNC:102477
Canis familiaris OARD1 VGNC VGNC:44085
Mus musculus OARD1 MGD MGI:2146818
Rattus norvegicus OARD1 RGD RGD:1308299
Macaca mulatta OARD1 VGNC VGNC:75444
Others OARD1 NCBI
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