2. Gene
  3. PARP10 - poly(ADP-ribose) polymerase family member 10 Gene

PARP10 - poly(ADP-ribose) polymerase family member 10 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族成员 10

种属: Homo sapiens

同用名: ARTD10

基因 ID: 84875 | 基因类型: protein coding

关于 PARP10

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,977,158-144,012,764 (from NCBI)

This gene has 23 transcripts (splice variants), 204 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 25.6), lymph node (RPKM 16.2) and 25 other tissues.

功能概要

聚 (ADP-核糖) 聚合酶 (PARP) ，例如 PARP10，通过向组蛋白添加 ADP-核糖来改变染色质组织，从而调节基因转录。 PARP 还可以作为转录辅助因子发挥作用 (Yu 等人，2005 [PubMed 15674325]) 。[OMIM 提供，2008 年 3 月]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

PARP10 基因产物(6)

mRNA Protein Name
NR_134234.2
XM_011517336.4 XP_011515638.1 protein mono-ADP-ribosyltransferase PARP10 isoform X2
XM_047422328.1 XP_047278284.1 protein mono-ADP-ribosyltransferase PARP10 isoform X3
XM_047422327.1 XP_047278283.1 protein mono-ADP-ribosyltransferase PARP10 isoform X1
NM_001317895.2 NP_001304824.1 protein mono-ADP-ribosyltransferase PARP10 isoform 2
NM_032789.5 NP_116178.2 protein mono-ADP-ribosyltransferase PARP10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15674325 GOA
enables K63-linked polyubiquitin modification-dependent protein binding IMP
IMP: 通过突变表型推断
23575687 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
18851833 GOA
enables NAD+-protein ADP-ribosyltransferase activity IMP
IMP: 通过突变表型推断
24695737 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: 通过突变表型推断
23473667 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22176891 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin organization IDA
IDA: 通过直接分析推断
15674325 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
23575687 GOA
involved in negative regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
15674325 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
23575687 GOA
involved in negative regulation of protein K63-linked ubiquitination IMP
IMP: 通过突变表型推断
23575687 GOA
involved in protein auto-ADP-ribosylation IDA
IDA: 通过直接分析推断
25043379 GOA
involved in protein auto-ADP-ribosylation IMP
IMP: 通过突变表型推断
23575687 GOA
involved in protein poly-ADP-ribosylation IDA
IDA: 通过直接分析推断
15674325 GOA
involved in protein poly-ADP-ribosylation IMP
IMP: 通过突变表型推断
23473667 GOA
involved in translesion synthesis IDA
IDA: 通过直接分析推断
24695737 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15674325 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15674325 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP10 蛋白结构

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (819 - 1004)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1025 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP10

ADP-ribosyltransferase diphtheria toxin-like 10

poly [ADP-ribose] polymerase 10

PARP10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PARP10 Q53GL7 OARD1 Homo sapiens Q9Y530
Enzymatic Study
23481255
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136979 RBN012759 Inhibitor 99.80% 否
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-123512 OUL35 Inhibitor 99.84% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-100225 ME0328 Inhibitor 99.64% 否
HY-143398 PARP10/15-IN-1 Inhibitor 95.00% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-146502 PARP10/15-IN-3 Inhibitor 99.98% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-146501 PARP10/15-IN-2 Inhibitor 99.00% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-W294889 OUL245 Inhibitor / 否
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / 否
HY-170542 ZINC20906412 Inhibitor / 否
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PARP10 VGNC VGNC:108106
Mus musculus PARP10 MGD MGI:3712326
Rattus norvegicus PARP10 RGD RGD:7744876
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