JAZF1 - JAZF zinc finger 1 Gene

中文名称：JAZF 锌指 1

种属: Homo sapiens

同用名: TIP27; ZNF802

基因 ID: 221895 | 基因类型: protein coding

关于 JAZF1

Cytogenetic location: 7p15.2-p15.1 Genomic coordinates (GRCh38): 7:27,830,577-28,180,795 (from NCBI)

This gene has 9 transcripts (splice variants), 265 orthologues and is associated with 64 phenotypes. Broad expression in adrenal (RPKM 50.1), endometrium (RPKM 20.1) and 20 other tissues.

功能概要

该基因编码具有三个 C2H2 型锌指的核蛋白，并作为转录抑制因子发挥作用。涉及该基因的染色体畸变与子宫内膜间质瘤有关。已经描述了编码不同蛋白质同种型的可变剪接变体；然而，并非所有变体都得到了充分表征[RefSeq 提供，2008 年 7 月]

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

JAZF1 基因产物(1)

mRNA	Protein	Name
NM_175061.4	NP_778231.2	juxtaposed with another zinc finger protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15302918	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	15302918	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15302918	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of transcription repressor complex	IDA IDA: 通过直接分析推断	15302918	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

juxtaposed with another zinc finger protein 1

TAK1-interacting protein 27

JAZF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	JAZF1	Q86VZ6	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
种属内	JAZF1	Q86VZ6	NR2C2	Homo sapiens	P49116	Anti Tag CoIP	33961781
种属内	JAZF1	Q86VZ6	NR2C2	Homo sapiens	P49116	Anti Tag CoIP	35016035
种属内	JAZF1	Q86VZ6	NR2C2	Homo sapiens	P49116	Proximity Labelling	35016035

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors

Endometrial Stromal Nodule

Vaginal Endometrial Stromal Sarcoma

Vagina Sarcoma

Sarcoma Of The Vagina

Vaginal Sarcoma

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Cellular Leiomyoma

Myxoid Leiomyosarcoma

Leiomyosarcoma, Myxoid

Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules	Ovarian Sex Cord-Stromal Tumor
Stromal Tumor Of Ovary

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Adenosarcoma

Mullerian Adenosarcoma

Atypical Polypoid Adenomyoma

Wolfram Syndrome 1

WFS1	Didmoad
Wfs	Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome
Wolfram Syndrome

Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma

Uterine Benign Neoplasm

Sarcomatosis

Reproductive Organ Benign Neoplasm

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07031	JAZF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	JAZF1	RGD	RGD:1589007
Canis familiaris	JAZF1	VGNC	VGNC:42182
Bos taurus	JAZF1	VGNC	VGNC:30372
Macaca mulatta	JAZF1	VGNC	VGNC:81626
Felis catus	JAZF1	VGNC	VGNC:80601
Mus musculus	JAZF1	MGD	MGI:2141450

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