NR2C2 - nuclear receptor subfamily 2 group C member 2 Gene

中文名称：核受体亚家族 2 C 组成员 2

种属: Homo sapiens

同用名: TR4; TAK1

关于 NR2C2

功能概要

该基因编码一种属于核激素受体家族的蛋白质。该家族的成员充当配体激活的转录因子，并在许多生物过程中发挥作用，例如发育、细胞分化和体内平衡。激活的受体/配体复合物易位到细胞核，在那里它与靶基因的激素反应元件结合。该基因编码的蛋白质在保护细胞免受氧化应激和电离辐射引起的损伤方面发挥作用。小鼠中缺乏类似基因会导致生长迟缓、严重的脊柱弯曲、生育能力低下、过早衰老和前列腺上皮内瘤变 (PIN) 的发展。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]