2. Gene
  3. Uchl1 - ubiquitin carboxy-terminal hydrolase L1 Gene

Uchl1 - ubiquitin carboxy-terminal hydrolase L1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: gad; PGP9.5; UCH-L1; UCHL-1; PGP 9.5

基因 ID: 22223 | 基因类型: protein coding

关于 Uchl1

功能概要

Enables thiol-dependent Deubiquitinase and ubiquitin binding activity. Involved in cellular response to xenobiotic stimulus. Acts upstream of or within several processes, including adult walking behavior; axon target recognition; and response to ischemia. Located in several cellular components, including axon; neuron projection terminus; and neuronal cell body. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]

Uchl1 基因产物(1)

mRNA Protein Name
NM_011670.2 NP_035800.2 ubiquitin carboxyl-terminal hydrolase isozyme L1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
12913066 MGI
enables ribosome binding IDA
IDA: 通过直接分析推断
23064229 MGI
enables ubiquitin binding IDA
IDA: 通过直接分析推断
12913066 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult walking behavior IGI
IGI: 通过遗传相互作用推断
11555633 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
3340629 MGI
acts upstream of or within axon target recognition IMP
IMP: 通过突变表型推断
8474599 MGI
acts upstream of or within axonal transport of mitochondrion IMP
IMP: 通过突变表型推断
2558488 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
1630580 MGI
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
23064229 MGI
acts upstream of or within eating behavior IGI
IGI: 通过遗传相互作用推断
11555633 MGI
acts upstream of or within male germ cell proliferation IMP
IMP: 通过突变表型推断
12638230 MGI
acts upstream of or within muscle cell development IGI
IGI: 通过遗传相互作用推断
8007658 MGI
acts upstream of or within neuromuscular process IMP
IMP: 通过突变表型推断
3340629 MGI
acts upstream of or within response to ischemia IMP
IMP: 通过突变表型推断
14695319 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
8896700 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12913066 MGI
located in cytosol IDA
IDA: 通过直接分析推断
12913066 MGI
located in neuron projection terminus IDA
IDA: 通过直接分析推断
24760869 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
11549719 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase isozyme L1

gracile axonal dystrophy

neuron cytoplasmic protein 9.5

protein gene product 9.5

ubiquitin thioesterase L1

重组 Uchl1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73466 UCHL1 Protein, Mouse (His) Q9R0P9 (Q2-A223) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153627 GK13S Inhibitor ≥98.0% 否
HY-161378 UCHL1-IN-1 Inhibitor ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Uchl1 NCBI NCBI:7345
Rattus norvegicus Uchl1 NCBI NCBI:29545
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