SCUBE3 - signal peptide, CUB domain and EGF like domain containing 3 Gene

中文名称：含信号肽、CUB 域和 EGF 样域 3

种属: Homo sapiens

同用名: CEGF3; SSFSC2

关于 SCUBE3

功能概要

该基因编码信号肽、补体子成分 C1r/C1s、Uegf、骨形态发生蛋白-1 和表皮生长因子样结构域蛋白家族的成员。该基因在人胚肾细胞中的过度表达导致糖基化形式的蛋白质分泌，形成寡聚体并连接到细胞表面。与健康组织相比，该基因在肺癌肿瘤组织中上调，并且与上皮标记物 E-钙粘蛋白的丢失以及波形蛋白 (一种间质标记物) 的表达增加有关。此外，该基因编码的蛋白是一种转化生长因子β受体配体，当被癌细胞分泌时，可在体外被切割释放出 N 端表皮生长因子样重复结构域和 C 端补体子组件 C1r/C1s 域。全长蛋白和 C 端片段均可与转化生长因子βII 型受体结合，促进上皮-间质转化和肿瘤血管生成。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 12 月]

This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung Cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by Cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]