2. Gene
  3. Mrtfa - myocardin related transcription factor A Gene

Mrtfa - myocardin related transcription factor A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mal; AMKL; Bsac; Mkl1; Mrtf-A

基因 ID: 223701 | 基因类型: protein coding

关于 Mrtfa

功能概要

Enables several functions, including DNA-binding transcription factor activity; actin monomer binding activity; and transcription coactivator activity. Involved in actin Cytoskeleton organization and positive regulation of transcription via serum response element binding activity. Acts upstream of or within negative regulation of apoptotic process; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in cerebellum; early conceptus; liver; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]

Mrtfa 基因产物(2)

mRNA Protein Name
NM_001082536.2 NP_001076005.2 myocardin-related transcription factor A isoform 2
NM_153049.3 NP_694629.2 myocardin-related transcription factor A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
17991879 MGI
enables actin binding IDA
IDA: 通过直接分析推断
15798203 MGI
enables actin monomer binding IDA
IDA: 通过直接分析推断
12732141 MGI
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
19008859 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12732141 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
17991879 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
12732141 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
24732378 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
20534669 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
20534669 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IDA
IDA: 通过直接分析推断
12019265 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
12019265 MGI
acts upstream of or within neuron migration IGI
IGI: 通过遗传相互作用推断
20534669 MGI
acts upstream of or within neuron projection development IGI
IGI: 通过遗传相互作用推断
20534669 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12019265 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17991879 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12732141 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12732141 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12019265 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

myocardin-related transcription factor A

MKL (megakaryoblastic leukemia)/myocardin-like 1

MKL/myocardin-like protein 1

basic SAP and coiled-coil domains

basic SAP coiled-coil transcription activator

megakaryoblastic leukemia (translocation) 1 homolog

megakaryocytic acute leukemia protein ho

Mrtfa 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Mrtfa Q8K4J6 KPNB1 Homo sapiens Q14974
Pull Down
20818336
种属间
Mrtfa Q8K4J6 ACTB Homo sapiens P60709
Pull Down
19008859
种属间
Mrtfa Q8K4J6 KPNA4 Homo sapiens O00629
Pull Down
20818336
种属间
Mrtfa Q8K4J6 ACTA1 Oryctolagus cuniculus P68135
X-Ray Diffraction
19008859
种属间
Mrtfa Q8K4J6 ACTA1 Oryctolagus cuniculus P68135
Fluorescence
19008859
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120855 CCG-100602 Inhibitor 99.85% 否
HY-13991A (S)-CCG-1423 / 否
HY-162968 MRTF-A-IN-1 Inhibitor / 否
HY-162969 MRTF-A-IN-2 Inhibitor / 否
HY-RS08693 MRTFA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mrtfa NCBI NCBI:57591
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z