2. Gene
  3. MAPK15 - mitogen-activated protein kinase 15 Gene

MAPK15 - mitogen-activated protein kinase 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶 15

种属: Homo sapiens

同用名: ERK7; ERK8

基因 ID: 225689 | 基因类型: protein coding

关于 MAPK15

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,716,349-143,722,458 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 197 orthologues and 19 paralogues. Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues.

功能概要

启用 MAP 激酶活性和染色质结合活性。参与多个过程，包括多巴胺摄取； DNA 代谢过程的正调控；和细胞器组织的调节。位于多种细胞成分中，包括高尔基体；自噬体；和微管组织中心。乳腺癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

MAPK15 基因产物(10)

mRNA Protein Name
XM_011516927.3 XP_011515229.1 mitogen-activated protein kinase 15 isoform X3
XM_011516925.3 XP_011515227.1 mitogen-activated protein kinase 15 isoform X1
XM_047421568.1 XP_047277524.1 mitogen-activated protein kinase 15 isoform X6
XM_047421567.1 XP_047277523.1 mitogen-activated protein kinase 15 isoform X5
XR_001745493.2
XM_047421566.1 XP_047277522.1 mitogen-activated protein kinase 15 isoform X4
XM_011516928.3 XP_011515230.1 mitogen-activated protein kinase 15 isoform X7
XM_011516926.3 XP_011515228.1 mitogen-activated protein kinase 15 isoform X2
XR_001745494.2
NM_139021.3 NP_620590.2 mitogen-activated protein kinase 15
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP kinase activity IDA
IDA: 通过直接分析推断
11875070 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
20733054 GOA
enables kinase activity IDA
IDA: 通过直接分析推断
19166846 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16624805 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
26595526 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
19166846 GOA
involved in dopamine uptake IDA
IDA: 通过直接分析推断
28842414 GOA
involved in endoplasmic reticulum organization IMP
IMP: 通过突变表型推断
21847093 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
24618899 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
20638370 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
20733054 GOA
acts upstream of positive regulation of telomere maintenance IDA
IDA: 通过直接分析推断
21531765 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21531765 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
11875070 GOA
involved in protein localization to ciliary transition zone IMP
IMP: 通过突变表型推断
29021280 GOA
involved in regulation of COPII vesicle coating IMP
IMP: 通过突变表型推断
24618899 GOA
involved in regulation of autophagy IDA
IDA: 通过直接分析推断
22948227 GOA
involved in regulation of cilium assembly IMP
IMP: 通过突变表型推断
29021280 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
24618899 GOA
located in autophagosome IDA
IDA: 通过直接分析推断
22948227 GOA
NOT located in axoneme IDA
IDA: 通过直接分析推断
29021280 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
29021280 GOA
located in centriole IDA
IDA: 通过直接分析推断
29021280 GOA
located in ciliary basal body IDA
IDA: 通过直接分析推断
29021280 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
20638370 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20638370 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPK15 蛋白结构

Pkinase

Pkinase: Protein kinase domain (15 - 304)

  • 0
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  • 544 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 15

ERK-7

ERK-8

MAP kinase 15

MAPK 15

extracellular regulated kinase 8 delta

extracellular signal-regulated kinase 7

extracellular signal-regulated kinase 8

MAPK15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAPK15 Q8TD08 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
MAPK15 Q8TD08 CDK2 Homo sapiens P24941
Anti Tag CoIP
25852190
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hemangioma Of Subcutaneous Tissue

Angioma Of The Subcutaneous Tissue

Subcutaneous Haemangioma

Subcutaneous Hemangioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135906 CK2/ERK8-IN-1 ≥99.0% 否
HY-RS08110 MAPK15 Human Pre-designed siRNA Set A / 否
HY-RS08111 Mapk15 Mouse Pre-designed siRNA Set A / 否
HY-RS08112 Mapk15 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MAPK15 VGNC VGNC:31217
Canis familiaris MAPK15 VGNC VGNC:42996
Macaca mulatta MAPK15 VGNC VGNC:74570
Mus musculus MAPK15 MGD MGI:2652894
Rattus norvegicus MAPK15 RGD RGD:628675
Others MAPK15 NCBI
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