2. Gene
  3. FRMPD1 - FERM and PDZ domain containing 1 Gene

FRMPD1 - FERM and PDZ domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 FERM 和 PDZ 结构域 1

种属: Homo sapiens

同用名: FRMD2

基因 ID: 22844 | 基因类型: protein coding

关于 FRMPD1

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:37,603,229-37,746,904 (from NCBI)

This gene has 3 transcripts (splice variants), 278 orthologues and 2 paralogues. Biased expression in testis (RPKM 3.6), skin (RPKM 1.1) and 2 other tissues.

功能概要

参与建立蛋白质膜定位和调节 G 蛋白偶联受体信号通路。位于质膜。部分含蛋白质复合物。与细胞皮层共定位。 [由基因组资源联盟提供，2022 年 4 月]

Involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of protein-containing complex. Colocalizes with cell cortex. [provided by Alliance of Genome Resources, Apr 2022]

FRMPD1 基因产物(4)

mRNA Protein Name
NM_001371223.1 NP_001358152.1 FERM and PDZ domain-containing protein 1
NM_001371224.1 NP_001358153.1 FERM and PDZ domain-containing protein 1
NM_001371225.1 NP_001358154.1 FERM and PDZ domain-containing protein 1
NM_014907.3 NP_055722.2 FERM and PDZ domain-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18566450 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of protein localization to membrane IMP
IMP: 通过突变表型推断
18566450 GOA
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
18566450 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with cell cortex IMP
IMP: 通过突变表型推断
18566450 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
18566450 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
22074847 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FRMPD1 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (65 - 131)

FERM_N

FERM_N: FERM N-terminal domain (189 - 264)

FERM_M

FERM_M: FERM central domain (274 - 401)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1578 a.a.
蛋白主名 其他名称

FERM and PDZ domain-containing protein 1

FERM domain-containing protein 2

FRMPD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FRMPD1 Q5SYB0 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Saccular Cerebral Aneurysm

Aneurysm, Intracranial Berry

Aneurysmal Subarachnoid Hemorrhage

Aneurysm, Intracranial Berry, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05107 FRMPD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FRMPD1 VGNC VGNC:52780
Felis catus FRMPD1 VGNC VGNC:62364
Rattus norvegicus FRMPD1 RGD RGD:1305229
Macaca mulatta FRMPD1 VGNC VGNC:72804
Mus musculus FRMPD1 MGD MGI:2446274
Canis familiaris FRMPD1 VGNC VGNC:51720
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