PDS5B - PDS5 cohesin associated factor B Gene

中文名称：PDS5 cohesin 相关因子 B

种属: Homo sapiens

同用名: AS3; APRIN; CG008

基因 ID: 23047 | 基因类型: protein coding

关于 PDS5B

Cytogenetic location: 13q13.1 Genomic coordinates (GRCh38): 13:32,586,452-32,778,019 (from NCBI)

This gene has 9 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 8.3), endometrium (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质与称为粘连蛋白的保守蛋白质复合物相互作用。 cohesin 复合物将姐妹染色单体结合在一起，并在有丝分裂和减数分裂过程中促进准确的染色体分离。这种蛋白质也是细胞增殖的负调节因子，可能是一种肿瘤抑制基因。[RefSeq 提供，2015 年 7 月]

This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

PDS5B 基因产物(1)

mRNA	Protein	Name
NM_015032.4	NP_055847.1	sister chromatid cohesion protein PDS5 homolog B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	19412548	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15837422	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitotic sister chromatid cohesion	IMP IMP: 通过突变表型推断	15855230	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	10963680	GOA
acts upstream of or within regulation of cell population proliferation	IDA IDA: 通过直接分析推断	10963680	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	16682347	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

sister chromatid cohesion protein PDS5 homolog B

androgen induced inhibitor of proliferation

PDS5B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PDS5B	Q9NTI5	WAPL	Homo sapiens	Q7Z5K2	Cosedimentation	17113138
种属内	PDS5B	Q9NTI5	WAPL	Homo sapiens	Q7Z5K2	Anti Bait CoIP	17112726
种属内	PDS5B	Q9NTI5	WAPL	Homo sapiens	Q7Z5K2	Anti Bait CoIP	17113138
种属内	PDS5B	Q9NTI5	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17113138
种属内	PDS5B	Q9NTI5	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	15855230
种属内	PDS5B	Q9NTI5	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	17113138
种属内	PDS5B	Q9NTI5	BRCA2	Homo sapiens	P51587	Anti Tag CoIP	22293751
种属内	PDS5B	Q9NTI5	BRCA2	Homo sapiens	P51587	Anti Bait CoIP	22293751
种属内	PDS5B	Q9NTI5	BRCA2	Homo sapiens	P51587	Y2H	22293751
种属内	PDS5B	Q9NTI5	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17113138
种属内	PDS5B	Q9NTI5	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	22293751
种属内	PDS5B	Q9NTI5	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	15855230
种属内	PDS5B	Q9NTI5	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17112726
种属内	PDS5B	Q9NTI5	RAD21	Homo sapiens	O60216	Anti Bait CoIP	15855230
种属内	PDS5B	Q9NTI5	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17113138
种属内	PDS5B	Q9NTI5	RAD21	Homo sapiens	O60216	Anti Bait CoIP	22293751

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Anemia Of Prematurity

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Tetraphocomelia-Cleft Palate Syndrome
Hypomelia Hypotrichosis Facial Hemangioma Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b	PHP1B
Pseudohypoparathyroidism Ib	Pseudohypoparathyroidism Type Ib
Php Ib	Pseudohypoparathyroidism 1b

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10292	PDS5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PDS5B	VGNC	VGNC:44393
Felis catus	PDS5B	VGNC	VGNC:64098
Macaca mulatta	PDS5B	VGNC	VGNC:75835
Mus musculus	PDS5B	MGD	MGI:2140945
Bos taurus	PDS5B	VGNC	VGNC:32718
Rattus norvegicus	PDS5B	RGD	RGD:1310838

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