WAPL - WAPL cohesin release factor Gene

中文名称：WAPL cohesin 释放因子

种属: Homo sapiens

同用名: FOE; WAPAL; KIAA0261

基因 ID: 23063 | 基因类型: protein coding

关于 WAPL

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,435,256-86,521,792 (from NCBI)

This gene has 4 transcripts (splice variants) and 295 orthologues. Ubiquitous expression in testis (RPKM 17.0), lymph node (RPKM 9.9) and 25 other tissues.

功能概要

参与多个过程，包括 DNA 复制的负调控；染色质结合活性的负调节；和调节姐妹染色单体的凝聚力。位于多种细胞成分中，包括高尔基体；细胞间桥；和微管细胞骨架。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

WAPL 基因产物(2)

mRNA	Protein	Name
NM_001318328.2	NP_001305257.1	wings apart-like protein homolog isoform 2
NM_015045.5	NP_055860.1	wings apart-like protein homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP-dependent protein-DNA unloader activity	IMP IMP: 通过突变表型推断	17113138	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17112726	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitotic sister chromatid segregation	IMP IMP: 通过突变表型推断	17113138	GOA
involved in negative regulation of DNA replication	IMP IMP: 通过突变表型推断	19907496	GOA
involved in negative regulation of chromatin binding	IMP IMP: 通过突变表型推断	17113138	GOA
involved in negative regulation of sister chromatid cohesion	IMP IMP: 通过突变表型推断	19696148	GOA
involved in protein localization to chromatin	IMP IMP: 通过突变表型推断	21111234	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	17113138	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17113138	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17113138	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WAPL 蛋白结构

WAPL

0
200
400
600
800
1000
1190 a.a.

蛋白主名

其他名称

wings apart-like protein homolog

friend of EBNA2 (Epstein-Barr virus nuclear protein 2)

WAPL 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	Pull Down	25173175
种属内	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	TAP	20360068
种属内	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17113138
种属内	WAPL	Q7Z5K2	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17112726
种属内	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	17113138
种属内	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	17112726
种属内	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	TAP	20360068
种属内	WAPL	Q7Z5K2	PDS5B	Homo sapiens	Q9NTI5	Cosedimentation	17113138
种属内	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17113138
种属内	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17112726
种属内	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Tag CoIP	26496610
种属内	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Anti Tag CoIP	35271311
种属内	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	TAP	20360068
种属内	WAPL	Q7Z5K2	RAD21	Homo sapiens	O60216	Pull Down	25173175

种属间: 跨种属相互作用 种属内: 同种属相互作用

WAPL 抗体

目录号	产品名	应用	反应物种
HY-P82652	WAPL Antibody (YA2397)	WB, ICC/IF, IP	Human

关联疾病

疾病名称

别名

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Tetraphocomelia-Cleft Palate Syndrome
Hypomelia Hypotrichosis Facial Hemangioma Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Warsaw Breakage Syndrome

WABS

WBRS

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15738	WAPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	WAPL	VGNC	VGNC:36862
Rattus norvegicus	WAPL	RGD	RGD:1590924
Macaca mulatta	WAPL	VGNC	VGNC:79384
Mus musculus	WAPL	MGD	MGI:2675859
Canis familiaris	WAPL	VGNC	VGNC:48330
Felis catus	WAPL	VGNC	VGNC:66998

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WAPL - WAPL cohesin release factor Gene

关于 WAPL

功能概要

WAPL 基因产物(2)

WAPL 蛋白结构

WAPL 蛋白互作信息

WAPL 抗体

关联疾病

直系同源

热门区域

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WAPL - WAPL cohesin release factor Gene

关于 WAPL

功能概要

WAPL 基因产物(2)

WAPL 蛋白结构

WAPL 蛋白互作信息

WAPL 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z