SMG1 - SMG1 nonsense mediated mRNA decay associated PI3K related kinase Gene

中文名称：SMG1 无义介导的 mRNA 衰变相关 PI3K 相关激酶

种属: Homo sapiens

同用名: ATX; LIP; 61E3.4

基因 ID: 23049 | 基因类型: protein coding

关于 SMG1

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:18,804,860-18,926,408 (from NCBI)

This gene has 16 transcripts (splice variants), 223 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 20.7), bone marrow (RPKM 12.3) and 25 other tissues.

功能概要

该基因编码一种参与无义介导的 mRNA 衰变 (NMD) 的蛋白质，作为 mRNA 监视复合体的一部分。该蛋白具有激酶活性，被认为通过磷酸化无义转录物调节蛋白 1 在 NMD 中发挥作用。已经描述了选择性剪接的转录物变体，但它们的全长性质尚未确定。[RefSeq 提供，2013 年 3 月]

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]

SMG1 基因产物(1)

mRNA	Protein	Name
NM_015092.5	NP_055907.3	serine/threonine-protein kinase SMG1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: 通过实验结果推断	11544179	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11544179	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	11544179	GOA
enables telomeric DNA binding	IDA IDA: 通过直接分析推断	17916692	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	15175154	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: 通过直接分析推断	11544179	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	11544179	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: 通过直接分析推断	11331269	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	11331269	GOA
involved in regulation of telomere maintenance	IMP IMP: 通过突变表型推断	17916692	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	14636577	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14636577	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMG1 蛋白结构

PI3_PI4_kinase

0
600
1200
1800
2400
3000
3661 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase SMG1

PI-3-kinase-related kinase SMG-1

SMG1 蛋白互作信息

分类种属内	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SMG1	Q96Q15	UPF2	Homo sapiens	Q9HAU5	Anti Tag CoIP	16452507
种属内	SMG1	Q96Q15	UPF2	Homo sapiens	Q9HAU5	Pull Down	20371770
种属内	SMG1	Q96Q15	UPF2	Homo sapiens	Q9HAU5	Anti Bait CoIP	18256688
种属内	SMG1	Q96Q15	UPF2	Homo sapiens	Q9HAU5	Anti Tag CoIP	19417104
种属内	SMG1	Q96Q15	UPF2	Homo sapiens	Q9HAU5	Anti Bait CoIP	16452507
种属内	SMG1	Q96Q15	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	16452507

种属间: 跨种属相互作用 种属内: 同种属相互作用

SMG1 抗体

目录号	产品名	应用	反应物种
HY-P82242	SMG1 Antibody (YA1987)	WB	Human, Mouse, Rat

关联疾病

疾病名称

别名

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Progressive Myoclonus Epilepsy 7

Epm7	Meak
Myoclonus Epilepsy And Ataxia Due To Potassium Channel Mutation	Pme Type 7
Progressive Myoclonic Epilepsy Due To Kv3.1 Deficiency	Progressive Myoclonus Epilepsy Type 7

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式 Inhibitor Pre-designed Sets	纯度	是否罕见病否
HY-161111	KVS0001	Inhibitor	99.14%	否
HY-RS13430	SMG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SMG1	VGNC	VGNC:65486
Macaca mulatta	SMG1	VGNC	VGNC:99591
Rattus norvegicus	SMG1	RGD	RGD:1563508
Bos taurus	SMG1	VGNC	VGNC:35010
Mus musculus	SMG1	MGD	MGI:1919742
Canis familiaris	SMG1	VGNC	VGNC:46554

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SMG1 - SMG1 nonsense mediated mRNA decay associated PI3K related kinase Gene

关于 SMG1

功能概要

SMG1 基因产物(1)

SMG1 蛋白结构

SMG1 蛋白互作信息

SMG1 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SMG1 - SMG1 nonsense mediated mRNA decay associated PI3K related kinase Gene

关于 SMG1

功能概要

SMG1 基因产物(1)

SMG1 蛋白结构

SMG1 蛋白互作信息

SMG1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z