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  2. Hcrtr1 - hypocretin (orexin) receptor 1 Gene

Hcrtr1 - hypocretin (orexin) receptor 1 Gene

中文名称:伪君子 (食欲素) 受体 1

种属: Mus musculus

同用名: Ox1r; ox1-R; ox-1-R

基因 ID: 230777 | 基因类型: protein coding

关于 Hcrtr1

Chromosome 4: 130,024,010-130,033,152 reverse strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 94 orthologues, 16 paralogues and is associated with 4 phenotypes. Biased expression in bladder adult (RPKM 6.3), stomach adult (RPKM 2.7) and 12 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动食欲素受体活性和肽激素结合活性。作用于 ERK1ERK2 级联的上游或正调控内。预测位于质膜中。预计是膜的组成部分。预计是质膜的组成部分。以多种结构表达,包括大脑;泌尿生殖系统;直觉;免疫系统;以及肝脏和胆道系统。与人类 HCRTR1(伪君子受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr1 基因产物(4)

mRNA Protein Name
NM_001305392.1 NP_001292321.1 orexin/Hypocretin receptor type 1 isoform 2
NM_001163027.1 NP_001156499.1 orexin/Hypocretin receptor type 1 isoform 1
NM_001357258.1 NP_001344187.1 orexin/Hypocretin receptor type 1 isoform 2
NM_198959.2 NP_945197.2 orexin/Hypocretin receptor type 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22028875 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
22028875 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hcrtr1 蛋白结构

7tmA_OXR

7tmA_OXR: cd15208 (46 - 368)

7tmA_OXR

7tmA_OXR: cd15208 (47 - 73)

7tmA_OXR

7tmA_OXR: cd15208 (80 - 106)

7tmA_OXR

7tmA_OXR: cd15208 (118 - 148)

7tmA_OXR

7tmA_OXR: cd15208 (159 - 180)

7tmA_OXR

7tmA_OXR: cd15208 (211 - 240)

7tmA_OXR

7tmA_OXR: cd15208 (290 - 320)

7tmA_OXR

7tmA_OXR: cd15208 (336 - 361)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

orexin/Hypocretin receptor type 1

orexin receptor type 1

hypocretin receptor type 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hcrtr1 NCBI NCBI:3061