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  3. HCRTR1 - hypocretin receptor 1 Gene

HCRTR1 - hypocretin receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：伪君子受体 1

种属: Homo sapiens

同用名: OX1R; OXR1; ORXR1

基因 ID: 3061 | 基因类型: protein coding

关于 HCRTR1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,617,689-31,634,492 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 16 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是参与摄食行为调节的 G 蛋白偶联受体。编码的蛋白质选择性地结合下丘脑神经肽食欲素 A。相关基因 (HCRTR2) 编码结合食欲素 A 和食欲素 B 的 G 蛋白偶联受体。[RefSeq 提供，2009 年 1 月]

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]

HCRTR1 基因产物(3)

mRNA Protein Name
XM_024446605.2 XP_024302373.1 orexin/Hypocretin receptor type 1 isoform X1
NM_001525.3 NP_001516.2 orexin/Hypocretin receptor type 1
XM_017001107.2 XP_016856596.1 orexin/Hypocretin receptor type 1 isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables orexin receptor activity IDA
IDA: 通过直接分析推断
26950369 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
31668922 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuropeptide signaling pathway IDA
IDA: 通过直接分析推断
26950369 GOA
involved in regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
26950369 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
26950369 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HCRTR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (63 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
蛋白主名 其他名称

orexin/Hypocretin receptor type 1

hypocretin (orexin) receptor 1

hypocretin receptor type 1

orexin receptor 1

orexin receptor type 1

HCRTR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HCRTR1 O43613 APLNR Homo sapiens P35414
BRET
31668922
种属内
HCRTR1 O43613 APLNR Homo sapiens P35414
IF
31668922
种属内
HCRTR1 O43613 APLNR Homo sapiens P35414
Anti Tag CoIP
31668922
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder
Morphine Dependence
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder
Eating Disorder

Eating Disorders

Feeding And Eating Disorders
Von Economo'S Disease

Encephalitis Lethargica

Von Economo Encephalitis

Von Economo Disease
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Adrenal Cortical Adenoma

Adrenocortical Adenoma

Adenoma Adrenocortical
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos
Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06051 HCRTR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06052 Hcrtr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06053 Hcrtr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HCRTR1 VGNC VGNC:41623
Rattus norvegicus HCRTR1 RGD RGD:2787
Macaca mulatta HCRTR1 VGNC VGNC:73356
Bos taurus HCRTR1 VGNC VGNC:29781
Mus musculus HCRTR1 MGD MGI:2385650
Felis catus HCRTR1 VGNC VGNC:67544
Others HCRTR1 NCBI
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