2. Gene
  3. MGRN1 - mahogunin ring finger 1 Gene

MGRN1 - mahogunin ring finger 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：mahogunin 无名指 1

种属: Homo sapiens

同用名: RNF156

基因 ID: 23295 | 基因类型: protein coding

关于 MGRN1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,624,826-4,690,972 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues.

功能概要

Mahogunin (MGRN1) 是一种含有 C3HC4 RING 的蛋白质，在体外具有 E3 泛素连接酶活性。[OMIM 提供，2004 年 4 月]

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin Ligase activity in vitro.[supplied by OMIM, Apr 2004]

MGRN1 基因产物(4)

mRNA Protein Name
NM_001142289.3 NP_001135761.2 E3 ubiquitin-protein ligase MGRN1 isoform 2
NM_001142290.3 NP_001135762.1 E3 ubiquitin-protein ligase MGRN1 isoform 3
NM_001142291.3 NP_001135763.2 E3 ubiquitin-protein ligase MGRN1 isoform 4
NM_015246.4 NP_056061.1 E3 ubiquitin-protein ligase MGRN1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17229889 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
17229889 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosome to lysosome transport IMP
IMP: 通过突变表型推断
17229889 GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
19737927 GOA
involved in protein monoubiquitination IMP
IMP: 通过突变表型推断
17229889 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17229889 GOA
located in early endosome IDA
IDA: 通过直接分析推断
17229889 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17229889 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19737927 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MGRN1 蛋白结构

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (275 - 321)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 552 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase MGRN1

RING finger protein 156

MGRN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MGRN1 O60291 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
25416956
种属内
MGRN1 O60291 TSG101 Homo sapiens Q99816
Y2H Array
19549727
种属内
MGRN1 O60291 TSG101 Homo sapiens Q99816
Validated Y2H
25416956
种属内
MGRN1 O60291 TSG101 Homo sapiens Q99816
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease

Gerstmann-Straussler-Scheinker Syndrome

Prion Dementia

Cerebral Amyloid Angiopathy, Prnp-Related

GSD

Gss

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns

Amyloidosis, Cerebral, With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type

Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type

Amyloidosis Cerebral With Spongiform Encephalopathy

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System

Encephalopathy Subacute Spongiform Gerstmann-Straussler Type

Gssd

Gerstmann Straussler Scheinker Syndrome

Cerebral Amyloidosis With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy Gerstmann-Straussler Type

Gluthathione Synthetase Deficiency

Gerstmann Straussler Syndrome
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08415 MGRN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MGRN1 VGNC VGNC:43214
Rattus norvegicus MGRN1 RGD RGD:1311862
Bos taurus MGRN1 VGNC VGNC:97285
Mus musculus MGRN1 MGD MGI:2447670
Macaca mulatta MGRN1 VGNC VGNC:74542
Felis catus MGRN1 VGNC VGNC:63491
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