2. Gene
  3. SIN3B - SIN3 transcription regulator family member B Gene

SIN3B - SIN3 transcription regulator family member B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SIN3 转录调节因子家族成员 B

种属: Homo sapiens

基因 ID: 23309 | 基因类型: protein coding

关于 SIN3B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,829,398-16,880,349 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 19.2), endometrium (RPKM 17.1) and 25 other tissues.

功能概要

预测启用转录辅阻遏物活性。预计参与组蛋白去乙酰化； RNA 聚合酶 II 对转录的负调控；和横纹肌组织发育。预测位于核内。预计是 Sin3 复合体的一部分。预计在染色质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription by RNA polymerase II; and striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SIN3B 基因产物(3)

mRNA Protein Name
NM_001297595.2 NP_001284524.1 paired amphipathic helix protein Sin3b isoform 2
NM_001297597.2 NP_001284526.1 paired amphipathic helix protein Sin3b isoform 3
NM_015260.4 NP_056075.1 paired amphipathic helix protein Sin3b isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12670868 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIN3B 蛋白结构

PAH

PAH: Paired amphipathic helix repeat (59 - 105)

PAH

PAH: Paired amphipathic helix repeat (180 - 236)

PAH

PAH: Paired amphipathic helix repeat (322 - 366)

Sin3_corepress

Sin3_corepress: Sin3 family co-repressor (393 - 444)

Sin3_corepress

Sin3_corepress: Sin3 family co-repressor (453 - 524)

  • 0
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  • 1000
  • 1162 a.a.
蛋白主名 其他名称

paired amphipathic helix protein Sin3b

SIN3 homolog B, transcriptional regulator

SIN3B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SIN3B O75182 MYC Homo sapiens P01106
CH-IP
24951594
种属内
SIN3B O75182 MYC Homo sapiens P01106
Confocal
24951594
种属内
SIN3B O75182 MYC Homo sapiens P01106
Anti Bait CoIP
24951594
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Witteveen-Kolk Syndrome

WITKOS

Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation

Sin3a-Related Intellectual Disability Syndrome
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12926 SIN3B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SIN3B MGD MGI:107158
Bos taurus SIN3B VGNC VGNC:34625
Macaca mulatta SIN3B VGNC VGNC:77276
Rattus norvegicus SIN3B RGD RGD:1587989
Canis familiaris SIN3B VGNC VGNC:46178
Felis catus SIN3B VGNC VGNC:65151
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