ARHGEF18 - Rho/Rac guanine nucleotide exchange factor 18 Gene

中文名称：Rho/Rac 鸟嘌呤核苷酸交换因子 18

种属: Homo sapiens

同用名: RP78; SA-RhoGEF; p114RhoGEF; P114-RhoGEF

关于 ARHGEF18

功能概要

Rho GTP 酶是调节广泛细胞功能的 GTP 结合蛋白。这些细胞过程包括细胞骨架重排、基因转录、细胞生长和运动。 Rho GTP 酶的激活受鸟嘌呤核苷酸交换因子 (GEF) 的直接控制。该基因编码的蛋白质是一种鸟嘌呤核苷酸交换因子，属于 Rho GTPase GEF 家族。家族成员有一个共同特征，即 Dbl (DH) 同源结构域后跟 pleckstrin (PH) 同源结构域。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2018 年 11 月]

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018]