2. Gene
  3. SIRT4 - sirtuin 4 Gene

SIRT4 - sirtuin 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 4

种属: Homo sapiens

同用名: SIR2L4

基因 ID: 23409 | 基因类型: protein coding

关于 SIRT4

Cytogenetic location: 12q24.23-q24.31 Genomic coordinates (GRCh38): 12:120,291,780-120,313,249 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 6 paralogues. Broad expression in testis (RPKM 2.4), kidney (RPKM 1.1) and 24 other tissues.

功能概要

该基因编码 沉默信息调节因子 2 相关酶类 蛋白家族的成员，与酵母 Sir2 蛋白同源。 沉默信息调节因子 2 相关酶类 家族的成员以 沉默信息调节因子 2 相关酶类 核心域为特征，分为四类。人类 沉默信息调节因子 2 相关酶类 s 的功能尚未确定；然而，已知酵母 沉默信息调节因子 2 相关酶类 蛋白可调节表观遗传基因沉默并抑制 rDNA 的重组。研究表明，人类 沉默信息调节因子 2 相关酶类 s 可能作为具有单 ADP 核糖基转移酶活性的细胞内调节蛋白发挥作用。由该基因编码的蛋白质属于 沉默信息调节因子 2 相关酶类 家族的 IV 类。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the Sirtuin family. [provided by RefSeq, Jul 2008]

SIRT4 基因产物(4)

mRNA Protein Name
NM_001385733.1 NP_001372662.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1
NM_001385734.1 NP_001372663.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 2
NM_001385735.1 NP_001372664.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 2
NM_012240.3 NP_036372.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
16959573 GOA
enables NAD-dependent protein biotinidase activity IDA
IDA: 通过直接分析推断
25525879 GOA
enables NAD-dependent protein lipoamidase activity IDA
IDA: 通过直接分析推断
25525879 GOA
NOT enables NAD-dependent protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
17715127 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16959573 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of fatty acid oxidation IMP
IMP: 通过突变表型推断
24043310 GOA
involved in negative regulation of insulin secretion IMP
IMP: 通过突变表型推断
17715127 GOA
involved in regulation of pyruvate dehydrogenase activity IDA
IDA: 通过直接分析推断
25525879 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
16959573 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
16079181 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIRT4 蛋白结构

SIR2

SIR2: Sir2 family (62 - 267)

  • 0
  • 100
  • 200
  • 314 a.a.
蛋白主名 其他名称

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

NAD-dependent ADP-ribosyltransferase sirtuin-4

关联疾病

疾病名称 别名
Hyperinsulinism

Hyperinsulinemia
Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis
Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163316 SIRT4-IN-1 Inhibitor 97.52% 否
HY-RS12946 SIRT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SIRT4 MGD MGI:1922637
Rattus norvegicus SIRT4 RGD RGD:1310413
Canis familiaris SIRT4 VGNC VGNC:46185
Macaca mulatta SIRT4 VGNC VGNC:100105
Felis catus SIRT4 VGNC VGNC:65158
Bos taurus SIRT4 VGNC VGNC:34633
Others SIRT4 NCBI
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