SLC25A5 - solute carrier family 25 member 5 Gene

中文名称：溶质载体家族 25 成员 5

种属: Homo sapiens

同用名: T2; T3; 2F1; AAC2; ANT2

基因 ID: 292 | 基因类型: protein coding

关于 SLC25A5

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,468,444-119,471,396 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 49 paralogues. Ubiquitous expression in duodenum (RPKM 370.1), small intestine (RPKM 299.2) and 25 other tissues.

功能概要

该基因是溶质载体蛋白基因线粒体载体亚家族的成员。该基因的产物起门控孔的作用，将 ADP 从细胞质转移到线粒体基质中，将 ATP 从线粒体基质转移到细胞质中。该蛋白质形成嵌入线粒体内膜的同型二聚体。该基因的抑制表达已被证明可诱导细胞凋亡并抑制肿瘤生长。人类基因组包含该基因的几个非转录假基因。[RefSeq 提供，2013 年 6 月]

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce Apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

SLC25A5 基因产物(1)

mRNA	Protein	Name
NM_001152.5	NP_001143.2	ADP/ATP translocase 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables adenine nucleotide transmembrane transporter activity	IMP IMP: 通过突变表型推断	19116139	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17715127	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	19725078	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenine nucleotide transport	IMP IMP: 通过突变表型推断	19116139	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP IMP: 通过突变表型推断	19154410	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	19154410	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MMXD complex	IDA IDA: 通过直接分析推断	20797633	GOA
located in membrane	IDA IDA: 通过直接分析推断	27641616	GOA
located in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	18063578	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A5 蛋白结构

Mito_carr

0
100
200
298 a.a.

蛋白主名

其他名称

ADP/ATP translocase 2

adenine nucleotide translocator 2 (fibroblast)

SLC25A5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC25A5	P05141	SIRT4	Homo sapiens	Q9Y6E7	Anti Tag CoIP	17715127
种属内	SLC25A5	P05141	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	21370995
种属内	SLC25A5	P05141	SLC35F6	Homo sapiens	Q8N357	Anti Tag CoIP	19154410

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Oncocytoma

Oxyphilic Adenoma	Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic	Hurthle Cell Tumor
Oncocytic Neoplasm

Hypertension And Brachydactyly Syndrome

Brachydactyly With Hypertension	Bilginturan Syndrome
HTNB	Brachydactyly-Arterial Hypertension Syndrome
Brachydactyly, Type E, With Short Stature And Hypertension	Bilginturan Brachydactyly
Brachydactyly Type E With Short Stature And Hypertension	Type E Brachydactyly With Short Stature And Hypertension
Brachydactyly Type E, With Short Stature And Hypertension	Hypertension With Brachydactyly

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13131	SLC25A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SLC25A5	VGNC	VGNC:54599
Rattus norvegicus	SLC25A5	RGD	RGD:620353
Bos taurus	SLC25A5	VGNC	VGNC:49966
Mus musculus	SLC25A5	MGD	MGI:1353496
Others	SLC25A5	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC25A5 - solute carrier family 25 member 5 Gene

关于 SLC25A5

功能概要

SLC25A5 基因产物(1)

SLC25A5 蛋白结构

SLC25A5 蛋白互作信息

关联疾病

直系同源

热门区域

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SLC25A5 - solute carrier family 25 member 5 Gene

关于 SLC25A5

功能概要

SLC25A5 基因产物(1)

SLC25A5 蛋白结构

SLC25A5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z