2. Gene
  3. CABIN1 - calcineurin binding protein 1 Gene

CABIN1 - calcineurin binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经钙蛋白结合蛋白 1

种属: Homo sapiens

同用名: CAIN; PPP3IN; KB-318B8.7

基因 ID: 23523 | 基因类型: protein coding

关于 CABIN1

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,011,304-24,178,628 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 212 orthologues. Ubiquitous expression in thyroid (RPKM 6.8), testis (RPKM 6.2) and 25 other tissues.

功能概要

钙调神经磷酸酶在 T 细胞受体介导的信号转导通路中起重要作用。由该基因编码的蛋白质特异性结合钙调神经磷酸酶的活化形式并抑制钙调神经磷酸酶介导的信号转导。编码的蛋白质存在于细胞核中，包含一个亮氨酸拉链结构域以及几个 PEST 基序，这些序列赋予包含它们的蛋白质靶向降解。可变剪接导致编码两种不同亚型的多个转录变体。[RefSeq 提供，2011 年 1 月]

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of Calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]

CABIN1 基因产物(3)

mRNA Protein Name
NM_001199281.1 NP_001186210.1 calcineurin-binding protein cabin-1 isoform a
NM_001201429.2 NP_001188358.1 calcineurin-binding protein cabin-1 isoform b
NM_012295.4 NP_036427.1 calcineurin-binding protein cabin-1 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12700764 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nucleosome assembly IDA
IDA: 通过直接分析推断
14718166 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CABIN1 蛋白结构

TPR_11

TPR_11: TPR repeat (92 - 155)

MEF2_binding

MEF2_binding: MEF2 binding (2156 - 2190)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2220 a.a.
蛋白主名 其他名称

calcineurin-binding protein cabin-1

calcineurin binding protein cabin 1

CABIN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CABIN1 Q9Y6J0 MEF2B Homo sapiens Q02080
EMSA
12700764
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colloid Adenoma

Macrofollicular Adenoma
Adiaspiromycosis
Fetal Adenoma

Microfollicular Adenoma
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01780 CABIN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CABIN1 VGNC VGNC:38621
Rattus norvegicus CABIN1 RGD RGD:620263
Felis catus CABIN1 VGNC VGNC:60283
Macaca mulatta CABIN1 VGNC VGNC:84563
Mus musculus CABIN1 MGD MGI:1298375
Bos taurus CABIN1 VGNC VGNC:26663
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