2. Gene
  3. DNPEP - aspartyl aminopeptidase Gene

DNPEP - aspartyl aminopeptidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天冬氨酰氨基肽酶

种属: Homo sapiens

同用名: DAP; ASPEP

基因 ID: 23549 | 基因类型: protein coding

关于 DNPEP

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,372,043-219,400,007 (from NCBI)

This gene has 21 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in small intestine (RPKM 15.5), duodenum (RPKM 15.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种氨肽酶，它更倾向于酸性氨基酸，特别倾向于天冬氨酸而不是谷氨酸。它被认为是一种参与细胞内蛋白质一般代谢的胞质蛋白。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 1 月]

The protein encoded by this gene is an Aminopeptidase which prefers acidic Amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DNPEP 基因产物(8)

mRNA Protein Name
NM_001319116.2 NP_001306045.1 aspartyl aminopeptidase isoform a
NM_001319117.2 NP_001306046.1 aspartyl aminopeptidase isoform b
NM_001319118.2 NP_001306047.1 aspartyl aminopeptidase isoform d
NM_001319119.2 NP_001306048.1 aspartyl aminopeptidase isoform d
NM_001319120.2 NP_001306049.1 aspartyl aminopeptidase isoform e
NM_001319121.2 NP_001306050.1 aspartyl aminopeptidase isoform f
NM_001319122.2 NP_001306051.1 aspartyl aminopeptidase isoform f
NM_012100.4 NP_036232.2 aspartyl aminopeptidase isoform c
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DNPEP 蛋白结构

Peptidase_M18

Peptidase_M18: Aminopeptidase I zinc metalloprotease (M18) (34 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
蛋白主名 其他名称

aspartyl aminopeptidase

DNPEP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DNPEP Q9ULA0 MPP1 Homo sapiens Q00013
Validated Y2H
25416956
种属内
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
种属内
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
种属内
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
种属内
DNPEP Q9ULA0 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
种属内
DNPEP Q9ULA0 SCAF8 Homo sapiens Q9UPN6
Anti Tag CoIP
33961781
种属内
DNPEP Q9ULA0 SCAF8 Homo sapiens Q9UPN6
Anti Tag CoIP
28514442
种属内
DNPEP Q9ULA0 TAE1 Saccharomyces cerevisiae P38340
Validated Y2H
27107014
种属内
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Y2H Prey Pooling
32296183
种属内
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Validated Y2H
32296183
种属内
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Y2H Array
25416956
种属内
DNPEP Q9ULA0 DNPEP Homo sapiens Q9ULA0
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I

TRPS1

Trichorhinophalangeal Syndrome Type I

Trps I

Trichorhinophalangeal Syndrome Type 1

Type I Trichorhinophalangeal Syndrome

Giedion Syndrome

Trp Syndrome

Tricho-Rhino-Phalangeal Syndrome 1

Trichorhinophalangeal Syndrome, Type Iii
Nemaline Myopathy 9

NEM9

Myopathy, Nemaline, Type 9
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03914 DNPEP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DNPEP VGNC VGNC:28148
Macaca mulatta DNPEP VGNC VGNC:71961
Mus musculus DNPEP MGD MGI:1278328
Rattus norvegicus DNPEP RGD RGD:1583848
Canis familiaris DNPEP VGNC VGNC:40038
Felis catus DNPEP VGNC VGNC:61564
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