MPP1 - MAGUK p55 scaffold protein 1 Gene

中文名称：MAGUK p55 支架蛋白 1

种属: Homo sapiens

同用名: MRG1; PEMP; AAG12; EMP55; DXS552E

关于 MPP1

功能概要

该基因编码膜相关鸟苷酸激酶 (MAGUK) 家族蛋白的原型。 MAGUK 与细胞骨架相互作用并调节细胞增殖、信号通路和细胞间连接。编码的蛋白质是一种广泛棕榈酰化的膜磷蛋白，包含一个 PDZ 结构域、一个 Src 同源 3 (SH3) 基序和一个鸟苷酸激酶结构域。该基因产物与不同组织和细胞类型中的各种细胞骨架蛋白和细胞连接蛋白相互作用，并可能参与细胞形状的调节、毛细胞发育、视网膜的神经模式以及顶端-基底极性和肿瘤抑制通路。非红细胞。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 10 月]

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the Cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]