2. Gene
  3. PADI4 - peptidyl arginine deiminase 4 Gene

PADI4 - peptidyl arginine deiminase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肽基精氨酸脱亚氨酶 4

种属: Homo sapiens

同用名: PAD; PAD4; PDI4; PDI5; PADI5

基因 ID: 23569 | 基因类型: protein coding

关于 PADI4

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,308,197-17,364,004 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 235 orthologues and 4 paralogues. Restricted expression toward bone marrow (RPKM 64.4).

功能概要

该基因是编码负责将精氨酸残基转化为瓜氨酸残基的酶的基因家族的成员。该基因可能在导致炎症和免疫反应的粒细胞和巨噬细胞发育中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene is a member of a gene family which encodes Enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

PADI4 基因产物(1)

mRNA Protein Name
NM_012387.3 NP_036519.2 protein-arginine deiminase type-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
16567635 GOA
enables histone H3R17 arginine deiminase activity IDA
IDA: 通过直接分析推断
15339660 GOA
enables histone H3R2 arginine deiminase activity IDA
IDA: 通过直接分析推断
15339660 GOA
enables histone H3R26 arginine deiminase activity IDA
IDA: 通过直接分析推断
15339660 GOA
enables histone H3R8 arginine deiminase activity IDA
IDA: 通过直接分析推断
15339660 GOA
enables histone arginine deiminase activity IDA
IDA: 通过直接分析推断
16567635 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15247907 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein-arginine deiminase activity IDA
IDA: 通过直接分析推断
21584310 GOA
enables protein-arginine deiminase activity IMP
IMP: 通过突变表型推断
15247907 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in post-translational protein modification IDA
IDA: 通过直接分析推断
15339660 GOA
involved in post-translational protein modification IMP
IMP: 通过突变表型推断
15247907 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15339660 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15247907 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PADI4 蛋白结构

PAD_N

PAD_N: Protein-arginine deiminase (PAD) N-terminal domain (1 - 111)

PAD_M

PAD_M: Protein-arginine deiminase (PAD) middle domain (113 - 273)

PAD

PAD: Protein-arginine deiminase (PAD) (278 - 663)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
蛋白主名 其他名称

protein-arginine deiminase type-4

HL-60 PAD

PADI4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PADI4 Q9UM07 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
种属内
PADI4 Q9UM07 POU6F2 Homo sapiens P78424
Y2H Array
32296183
种属内
PADI4 Q9UM07 ANXA4 Homo sapiens P09525
Y2H Array
25416956
种属内
PADI4 Q9UM07 ANXA4 Homo sapiens P09525
Validated Y2H
25416956
种属内
PADI4 Q9UM07 ANXA4 Homo sapiens P09525
Y2H Prey Pooling
25416956
种属内
PADI4 Q9UM07 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
种属内
PADI4 Q9UM07 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PADI4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70990 PADI4 Protein, Human (His) Q9UM07/AAH25718.1 (M1-P663) ≥95%
HY-P701030 PADI4 Protein, Human (Biotinylated, His) Q9UM07/AAH25718.1 (M1-P663) ≥95%

关联疾病

疾病名称 别名
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Felty Syndrome

Felty'S Syndrome

Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia

Familial Felty'S Syndrome

Rheumatoid Arthritis, Splenomegaly And Neutropenia

Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome

Feltys Syndrome
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Caplan'S Syndrome

Caplan Syndrome

Caplan'S Disease

Caplans Syndrome

Rheumatoid Pneumoconiosis
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Cervical Polyp

Cervix Adenomatous Polyp
Papillon-Lefevre Syndrome

Papillon-Lefevre Disease

Papillon-Lefèvre Syndrome

PLS

Keratosis Palmoplantaris With Periodontopathia

PALS

Papillon Lefevre Syndrome

Keratosis Palmoplantar-Periodontopathy Syndrome

Papillon-Lefvre Syndrome

Hyperkeratosis Palmoplantaris With Periodontosis

Keratoris Palmoplantaris With Periodontopathia

Keratosis Palmoplantar - Periodontopathy

Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction

Palmoplantar Keratoderma With Periodontosis

Palsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09963 PADI4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PADI4 VGNC VGNC:80298
Canis familiaris PADI4 VGNC VGNC:44237
Macaca mulatta PADI4 VGNC VGNC:100024
Rattus norvegicus PADI4 RGD RGD:3290
Bos taurus PADI4 VGNC VGNC:32548
Mus musculus PADI4 MGD MGI:1338898
Macaca fascicularis PADI4 NCBI NCBI:102126460
Others PADI4 NCBI
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