2. Gene
  3. SLC7A11 - solute carrier family 7 member 11 Gene

SLC7A11 - solute carrier family 7 member 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 7 成员 11

种属: Homo sapiens

同用名: xCT; CCBR1

基因 ID: 23657 | 基因类型: protein coding

关于 SLC7A11

Cytogenetic location: 4q28.3 Genomic coordinates (GRCh38): 4:138,164,097-138,312,671 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 12 paralogues. Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues.

功能概要

该基因编码异聚的、不依赖钠的阴离子氨基酸转运系统的成员，该系统对半胱氨酸和谷氨酸具有高度特异性。在这个系统中，指定为 Xc (-) ，半胱氨酸的阴离子形式被运输以交换谷氨酸。这种蛋白质已被确定为卡波西肉瘤相关疱疹病毒融合和进入细胞的主要介质。此外，该基因在原发性神经胶质瘤中的表达增加 (与正常脑组织相比) 与通过 XCT 通道的谷氨酸分泌增加有关，从而导致神经元细胞死亡。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

SLC7A11 基因产物(1)

mRNA Protein Name
NM_014331.4 NP_055146.1 cystine/glutamate transporter
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-kynurenine transmembrane transporter activity IDA
IDA: 通过直接分析推断
35245456 GOA
enables cystine:glutamate antiporter activity IDA
IDA: 通过直接分析推断
11417227 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21397861 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-cystine transport IDA
IDA: 通过直接分析推断
11133847 GOA
involved in L-glutamate transmembrane transport IDA
IDA: 通过直接分析推断
11133847 GOA
involved in L-kynurenine transmembrane transport IDA
IDA: 通过直接分析推断
35245456 GOA
involved in negative regulation of ferroptosis IDA
IDA: 通过直接分析推断
35245456 GOA
involved in response to toxic substance IDA
IDA: 通过直接分析推断
17575980 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
25063885 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11417227 GOA
located in plasma membrane IPI
IPI: 通过物理相互作用推断
34880232 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC7A11 蛋白结构

AA_permease_2

AA_permease_2: Amino acid permease (46 - 458)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
蛋白主名 其他名称

cystine/glutamate transporter

amino acid transport system xc-

SLC7A11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC7A11 Q9UPY5 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
SLC7A11 Q9UPY5 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
SLC7A11 Q9UPY5 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
SLC7A11 Q9UPY5 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
SLC7A11 Q9UPY5 CD44 Homo sapiens P16070
Anti Bait CoIP
21397861
种属间: 跨种属相互作用 种属内: 同种属相互作用

SLC7A11 抗体

目录号 产品名 应用 反应物种
HY-P80935 xCT Antibody (YA006) WB, IP Human, Mouse

关联疾病

疾病名称 别名
Lysinuric Protein Intolerance

LPI

Dibasic Amino Aciduria Ii

Hyperdibasic Aminoaciduria

Dibasic Aminoaciduria 2

Dibasicamino Aciduria Ii

Congenital Lysinuria

Lpi - Lysinuric Protein Intolerance
Cystinuria

CSNU

Cystinuria Type B

Cystinuria Type A

Cystinuria, Type I, Formerly

Csnu1, Formerly

Cystinuria, Type Ii, Formerly

Cystinuria, Type Iii, Formerly

Csnu3, Formerly

Cystinuria, Type Non-I, Formerly

Cystinuria-Lysinuria

Cystinuria-Lysinuria Syndrome

Csnu1

Csnu3

Cystinuria 1

Cystinuria Type A/B

Cystinuria Type I

Cystinuria Type Ii

Cystinuria Type Iii

Cystinuria Type Non-I

Cystinuria, Type A/B

Cystinuria Type 1

Cystinuria - Lysinuria

Csnu - [Cystinuria]

Cystine Disease
Kaposi Sarcoma

Kaposi'S Sarcoma

Kaposi Sarcoma, Susceptibility To

Kaposi'S Sarcoma Of Lung

Kaposi'S Sarcoma Of Palate

Kaposi'S Sarcoma Of Soft Tissue

Kaposi'S Sarcoma-Associated Herpesvirus

Multiple Idiopathic Pigmented Hemangiosarcoma

Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

African Lymphadenopathic Kaposi'S Sarcoma

Anal Kaposi'S Sarcoma

Cardiac Kaposi'S Sarcoma

Central Nervous System Kaposi'S Sarcoma

Conjunctival Kaposi'S Sarcoma

Corneal Kaposi'S Sarcoma

Cutaneous Kaposi'S Sarcoma

Esophageal Kaposi'S Sarcoma

Gallbladder Kaposi'S Sarcoma

Gastric Kaposi'S Sarcoma

Intestinal Kaposi'S Sarcoma

Kaposi'S Sarcoma Of Anus

Kaposi'S Sarcoma Of Central Nervous System

Kaposi'S Sarcoma Of Conjunctiva

Kaposi'S Sarcoma Of Cornea

Kaposi'S Sarcoma Of Esophagus

Kaposi'S Sarcoma Of Gastrointestinal Sites

Kaposi'S Sarcoma Of Heart

Kaposi'S Sarcoma Of Lymph Nodes

Kaposi'S Sarcoma Of Penis

Kaposi'S Sarcoma Of Skin

Kaposi'S Sarcoma Of Soft Tissues

Kaposi'S Sarcoma Of The Cns

Kaposi'S Sarcoma Of The Gallbladder

Kaposi'S Sarcoma Of The Prostate

Kaposi'S Sarcoma, Lung

Kaposi'S Sarcoma, Skin

Lymph Node Kaposi'S Sarcoma

Lymphadenopathic Kaposi'S Sarcoma

Palate Kaposi'S Sarcoma

Penis Kaposi'S Sarcoma

Prostate Kaposi'S Sarcoma

Pulmonary Kaposi'S Sarcoma

Soft Tissue Kaposi'S Sarcoma

Hhv8

Human Herpesvirus 8

Kshv

Kaposi Sarcoma Herpesvirus

Mediterranean Kaposi Sarcoma

Non Aids Related Kaposi Sarcoma

Sarcoma, Kaposi

Sarcoma, Kaposi, Susceptibility To

Non-Aids-Related Kaposi Sarcoma

Angiolymphoid Hyperplasia

Angiofollicular Ganglionic Hyperplasia

Multi-Centric Castleman'S Disease
Occlusion Of Gallbladder

Obstruction Of Gallbladder

Gallbladder Obstruction
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Brain Edema

Cerebral Edema

Intracranial Swelling

Wet Brain
Thyrotoxic Exophthalmos
Endocrine Exophthalmos

Endocrine Exopthalmos

Thyroid Associated Opthalmopathies
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Developmental And Epileptic Encephalopathy 75

DEE75

Epileptic Encephalopathy, Early Infantile, 75

Eiee75

Developmental And Epileptic Encephalopathy, 75

Early Infantile Epileptic Encephalopathy 75
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0653A Levobupivacaine hydrochloride 99.98% 是
HY-B0653 Levobupivacaine / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-W402682 SXC2023 Inhibitor 99.83% Phase 2
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15763 Erastin 99.76% 否
HY-W451275 HG106 Activator 99.95% 否
HY-149979 SLC7A11-IN-1 Inducer 95.93% 否
HY-RS13325 SLC7A11 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-155851 Lepadin E / 否
HY-155852 Lepadin H Inducer / 否
HY-161075 Microtubule inhibitor 8 / 否
HY-162942 SLC7A11-IN-3 Inhibitor / 否
HY-169056 SLC7A11-IN-2 / 否
HY-B0653AS Levobupivacaine-d9 hydrochloride / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC7A11 MGD MGI:1347355
Canis familiaris SLC7A11 VGNC VGNC:46472
Rattus norvegicus SLC7A11 RGD RGD:1309275
Bos taurus SLC7A11 VGNC VGNC:34926
Macaca mulatta SLC7A11 VGNC VGNC:77628
Felis catus SLC7A11 VGNC VGNC:65423
Others SLC7A11 NCBI
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