2. Gene
  3. IL17RA - interleukin 17 receptor A Gene

IL17RA - interleukin 17 receptor A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白介素 17 受体 A

种属: Homo sapiens

同用名: CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R

基因 ID: 23765 | 基因类型: protein coding

关于 IL17RA

Cytogenetic location: 22q11.1 Genomic coordinates (GRCh38): 22:17,085,000-17,115,693 (from NCBI)

This gene has 8 transcripts (splice variants), 241 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues.

功能概要

白细胞介素 17A (IL17A) 是由活化的 T 淋巴细胞分泌的促炎细胞因子。它是 CD34 阳性造血前体成熟为嗜中性粒细胞的有效诱导剂。由该基因编码的跨膜蛋白 (白细胞介素 17A 受体；IL17RA) 是一种普遍存在的 I 型膜糖蛋白，它与白细胞介素 17A 的结合亲和力低。白介素 17A 及其受体在许多炎症和自身免疫性疾病 (如类风湿性关节炎) 中起致病作用。与其他细胞因子受体一样，该受体可能具有多聚体结构。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 2 月]

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other Cytokine Receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

IL17RA 基因产物(2)

mRNA Protein Name
NM_001289905.2 NP_001276834.1 interleukin-17 receptor A isoform 2 precursor
NM_014339.7 NP_055154.3 interleukin-17 receptor A isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-17 receptor activity IDA
IDA: 通过直接分析推断
27184415 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21993848 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fibroblast activation IDA
IDA: 通过直接分析推断
21145111 GOA
involved in interleukin-17-mediated signaling pathway IDA
IDA: 通过直接分析推断
33723527 GOA
involved in interleukin-17-mediated signaling pathway IMP
IMP: 通过突变表型推断
21350122 GOA
involved in interleukin-17A-mediated signaling pathway IDA
IDA: 通过直接分析推断
9367539 GOA
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
IMP: 通过突变表型推断
21350122 GOA
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: 通过直接分析推断
33723527 GOA
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
33723527 GOA
involved in positive regulation of interleukin-23 production IDA
IDA: 通过直接分析推断
21145111 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
21350122 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
33723527 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL17RA 蛋白结构

SEFIR

SEFIR: SEFIR domain (378 - 535)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 866 a.a.
蛋白主名 其他名称

interleukin-17 receptor A

IL-17 receptor A

IL17RA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
IL17RA Q96F46 ns8_sars2 SARS-CoV-2 P0DTC8
Pull Down
33060197
种属内
IL17RA Q96F46 IL17RE Homo sapiens Q8NFR9
Anti Tag CoIP
21993848
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL17RA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70892 IL-17RA Protein, Human (HEK293, His) Q96F46-1(L33-W320) ≥95%
HY-P71963 IL-17RA Protein, Human (HEK293, hFc) Q96F46-1(L33-W320) ≥95%
HY-P78147 IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi) Q96F46-1(L33-W320) ≥95%
HY-P78161 IL-17RA Protein, Human (Biotinylated, HEK293, His-Avi) Q96F46-1(L33-W320) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 51

IMD51

Candf5

Candidiasis, Familial, 5

Candidiasis, Familial, 5, Formerly

Candf5, Formerly

Familial Candidiasis 5

Candidiasis Familial 5 Autosomal Recessive

Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

Chronic Mucocutaneous Candidiasis 5
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Psoriasis
Folliculitis
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
Colitis
Cutaneous Candidiasis

Candidiasis, Cutaneous
Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome

Hyper-Ige Recurrent Infection Syndrome 1

Hyperimmunoglobulin E Syndrome

Job'S Syndrome

Recurring Cold Staphylococcal Abscesses

Ige Syndromes

Buckley Syndrome

Hie - [Hyperimmunoglobulin E] Syndrome

Job-Buckley Syndrome

Quie-Hill Syndrome
Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses
Fungal Infectious Disease

Mycoses

Mycosis
Oral Candidiasis

Thrush

Candidiasis Of Mouth

Oral Moniliasis

Thrush, Oral

Candidiasis, Oral

Oral Thrush

Candidiasis

Equine Thrush
Autoimmune Polyendocrine Syndrome

Autoimmune Polyendocrinopathy

Autoimmune Polyglandular Failure

Autoimmune Polyglandular Syndrome

Polyendocrinopathies, Autoimmune

Lloyd'S Syndrome

Aps

Polyendocrinopathies Autoimmune

Polyendocrine Autoimmunity Syndrome

Lloyd Syndrome

Polyglandular Autoimmune Deficiency

Progressive Pluriglandular Insufficiency

Pluriglandular Autoimmune Atrophy

Pluriglandular Autoimmune Syndrome

Thyroid-Adrenocortical Insufficiency Syndrome
Autoimmune Polyendocrine Syndrome Type 1

Whitaker Syndrome

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

Autoimmune Polyglandular Syndrome I

Polyglandular Type I Autoimmune Syndrome
Autoimmune Disease Of Skin And Connective Tissue
Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina

Candidiasis, Vulvovaginal

Candidal Vulvovaginitis

Candidal: Cervix

Monilial Vulvovaginitis

Candidiasis Vulvovaginal
Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis
Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease
Ankylosing Spondylitis 1

Ankylosing Spondylitis, Susceptibility To, 1
Spondyloarthropathy

Spondylarthropathies

Spondarthropathy

Spondylarthrosis

Spondyloarthropathy, Susceptibility To

Spondylarthritis
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Meningovascular Neurosyphilis
Psoriasis 11

PSORS11

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Psoriasis 11, Susceptibility To

Pv
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P9924 Ixekizumab Inhibitor 98.90% 否
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06702 IL17RA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus IL17RA VGNC VGNC:67763
Canis familiaris IL17RA VGNC VGNC:41946
Macaca mulatta IL17RA VGNC VGNC:73712
Mus musculus IL17RA MGD MGI:107399
Rattus norvegicus IL17RA RGD RGD:1306559
Bos taurus IL17RA VGNC VGNC:30122
Others IL17RA NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z