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  2. Mapk7 - mitogen-activated protein kinase 7 Gene

Mapk7 - mitogen-activated protein kinase 7 Gene

中文名称:丝裂原活化蛋白激酶 7

种属: Mus musculus

同用名: BMK1; ERK5; BMK-1; ERK-5; PRKM7; Erk5-T; b2b2346Clo

基因 ID: 23939 | 基因类型: protein coding

关于 Mapk7

Chromosome 11: 61,379,638-61,385,232 reverse strand.GRCm39:CM001004.3

This gene has 14 transcripts (splice variants), 193 orthologues, 19 paralogues and is associated with 50 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 31.7), whole brain E14.5 (RPKM 29.9) and 27 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与蛋白质磷酸化。作用于多个过程的上游或内部,包括细胞内信号转导的负调节;肽基丝氨酸磷酸化;和血管生成的调节。位于细胞质和细胞核中。以多种结构表达,包括心血管系统;早孕;神经节;泌尿生殖系统;和唾液腺。与人 MAPK7(丝裂原活化蛋白激酶 7)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including negative regulation of intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of angiogenesis. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; ganglia; genitourinary system; and salivary gland. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Mapk7 基因产物(7)

mRNA Protein Name
NM_011841.2 NP_035971.1 mitogen-activated protein kinase 7 isoform a
NM_001361989.1 NP_001348918.1 mitogen-activated protein kinase 7 isoform c
NM_001291036.1 NP_001277965.1 mitogen-activated protein kinase 7 isoform c
NM_001291034.1 NP_001277963.1 mitogen-activated protein kinase 7 isoform a
NM_001291035.1 NP_001277964.1 mitogen-activated protein kinase 7 isoform c
NM_001291037.1 NP_001277966.1 mitogen-activated protein kinase 7 isoform d
NM_001291033.1 NP_001277962.1 mitogen-activated protein kinase 7 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14515274 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
14515274 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18347059 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
18347059 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
14675480 MGI
acts upstream of or within negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
18347059 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
18347059 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
14515274 MGI
acts upstream of or within regulation of angiogenesis IMP
IMP: 通过突变表型推断
12221099 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
18347059 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18347059 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Mapk7 蛋白结构

STKc_ERK5

STKc_ERK5: cd07855 (48 - 383)

  • 0
  • 200
  • 400
  • 600
  • 806 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 7

MAPK 7

big MAP kinase 1

extracellular signal-regulated kinase 5

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapk7 NCBI NCBI:5598