Nt5e - 5' nucleotidase, ecto Gene

中文名称：5 '核苷酸酶，胞外

种属: Mus musculus

同用名: NT; Nt5; eNT; CD73; 5'-NT; 2210401F01Rik

关于 Nt5e

功能概要

该基因编码一种膜结合核苷酸酶，可水解细胞外核苷一磷酸。编码的前原蛋白经过蛋白水解加工，生成功能性同型二聚体酶，该酶优先使用腺苷一磷酸作为底物生成游离腺苷。缺乏编码蛋白的小鼠表现出停止流动压力和浅表肾单位肾小球滤过率的显着降低，以响应肾小管灌注流量的饱和增加。 [RefSeq 提供，2016 年 9 月]

This gene encodes a membrane-bound nucleotidase that hydrolyzes extracellular nucleoside monophosphates. The encoded preproprotein undergoes proteolytic processing to generate to a functional, homodimeric Enzyme that preferentially uses adenosine monophosphate as a substrate to generate free adenosine. Mice lacking the encoded protein exhibit a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow. [provided by RefSeq, Sep 2016]