Agtr1a - angiotensin II receptor, type 1a Gene

种属: Rattus norvegicus

同用名: AT1; AT1A; AT1R; Agtr1

基因 ID: 24180 | 基因类型: protein coding

关于 Agtr1a

功能概要

Enables D1 Dopamine Receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cation homeostasis; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Agtr1a 基因产物(2)

mRNA	Protein	Name
NM_030985.4	NP_112247.2	type-1 angiotensin II receptor A
NM_030985.4	NP_112247.2	type-1 angiotensin II receptor A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables D1 dopamine receptor binding	IPI IPI: 通过物理相互作用推断	22193384	RGD
enables angiotensin type I receptor activity	IDA IDA: 通过直接分析推断	2041570	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	14559250	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	9287353	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	9092554	RGD
involved in activation of Janus kinase activity	IMP IMP: 通过突变表型推断	9314843	RGD
involved in angiotensin-activated signaling pathway	IMP IMP: 通过突变表型推断	21769867	RGD
involved in cellular response to dexamethasone stimulus	IDA IDA: 通过直接分析推断	17537984	RGD
involved in dopamine biosynthetic process	IMP IMP: 通过突变表型推断	20097214	RGD
involved in drinking behavior	IMP IMP: 通过突变表型推断	9622148	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	11906170	RGD
involved in positive regulation of angiogenesis	IMP IMP: 通过突变表型推断	32324784	RGD
involved in positive regulation of blood pressure	IMP IMP: 通过突变表型推断	20702798	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: 通过突变表型推断	17537984	RGD
involved in positive regulation of calcium ion import across plasma membrane	IMP IMP: 通过突变表型推断	15569855	RGD
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	22645419	RGD
involved in positive regulation of receptor recycling	IDA IDA: 通过直接分析推断	14559250	RGD
involved in positive regulation of superoxide anion generation	IMP IMP: 通过突变表型推断	21076237	RGD
involved in regulation of pH	IDA IDA: 通过直接分析推断	11906170	RGD
involved in renin-angiotensin regulation of aldosterone production	IMP IMP: 通过突变表型推断	21318332	RGD
involved in response to activity	IEP IEP: 通过表达模式推断	18252761	RGD
involved in response to angiotensin	IEP IEP: 通过表达模式推断	8986922	RGD
involved in response to corticosterone	IEP IEP: 通过表达模式推断	7594440	RGD
involved in response to estrogen	IDA IDA: 通过直接分析推断	12810582	RGD
involved in response to estrogen	IEP IEP: 通过表达模式推断	15544836	RGD
involved in response to salt stress	IEP IEP: 通过表达模式推断	9095078	RGD
involved in vasoconstriction	IMP IMP: 通过突变表型推断	20955746	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	14559250	RGD
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	12110004	RGD
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	14559250	RGD
located in dendrite	IDA IDA: 通过直接分析推断	15590154	RGD
located in organelle outer membrane	IDA IDA: 通过直接分析推断	15590154	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	14559250	RGD
located in recycling endosome	IDA IDA: 通过直接分析推断	14559250	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

type-1 angiotensin II receptor A

type-1A angiotensin II receptor

AT1 receptor A	angiotensin II type-1 receptor A
angiotensin II type-1A receptor	angiotensin receptor 1a
vascular type-1 angiotensin II receptor

Agtr1a 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Agtr1	P25095	AGT	Homo sapiens	P01019	Saturation Binding	18202720

种属间: 跨种属相互作用 种属内: 同种属相互作用

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