Serpine1 - serpin family E member 1 Gene

中文名称：serpin 家族 E 成员 1

种属: Rattus norvegicus

同用名: Pai1; PAI1A; Planh; Pai1aa; RATPAI1A

关于 Serpine1

功能概要

该基因编码的蛋白可启动蛋白酶结合活性和丝氨酸型内肽酶抑制剂活性。参与多个过程，包括细胞对生长因子刺激的反应；细胞对激素刺激的反应；和细胞对有机氮化合物的反应。位于嗜铬颗粒和细胞外空间。用于研究多种疾病，包括动脉疾病（多种）；脑血管疾病（多发）；糖尿病（多发性）；晚期肾脏疾病;和肾纤维化。多种疾病的生物标志物，包括急性坏死性胰腺炎；肾小球硬化症（多发性）；肺部疾病（多发）；大脑中动脉梗塞;和肌肉萎缩。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；自身免疫性疾病（多种）；糖尿病视网膜病变（多发性）；肝病（多发性）；和肺部疾病（多种）。与人类 SERPINE1（丝氨酸蛋白酶抑制剂家族 E 成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]