IL27 - interleukin 27 Gene

中文名称：白细胞介素 27

种属: Homo sapiens

同用名: p28; IL30; IL-27; IL27A; IL-27A; IL27p28

关于 IL27

功能概要

该基因编码的蛋白质是异二聚体细胞因子复合物的亚基之一。这种蛋白质与白细胞介素 12A (IL12A) 有关。它与 Epstein-Barr 病毒诱导基因 3 (EBI3) 相互作用，后者是一种类似于白细胞介素 12B (IL12B) 的蛋白质，并形成一种复合物，该复合物已被证明可驱动幼稚而非记忆 CD4 (+) T 细胞的快速扩增。还发现该复合物与白细胞介素 12 有强烈的协同作用，可触发幼稚 CD4 (+) T 细胞的干扰素γ (IFNG) 产生。这种细胞因子的生物学效应由 I 类细胞因子受体 (WSX1/TCRR) 介导。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]